Evidence map›Paper›PMID 28765220›Full record

ArticlemBio2017

Nitrite Derived from Endogenous Bacterial Nitric Oxide Synthase Activity Promotes Aerobic Respiration.

Sujata S Chaudhari, Minji Kim, Shulei Lei, Fareha Razvi, Abdulelah A Alqarzaee, Elizabeth H Hutfless, Robert Powers, Matthew C Zimmerman, Paul D Fey, Vinai C Thomas

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  4. ArgT functions as an arginine transporter inJournal of bacteriology · 2025
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  5. Growth and acetate metabolism ofApplied and environmental microbiology · 2025
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  8. Factors impacting the regulation ofMicrobiology spectrum · 2023
    Article
  9. Review
  10. Heme A Synthase Deficiency Affects the Ability ofInternational journal of molecular sciences · 2022
    Article
  11. Review
  12. Article
  13. Quantifying Staphylococcus aureus Membrane Potential Using Flow Cytometry.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. A nitric oxide synthase-like protein fromThe Journal of biological chemistry · 2019
    Article
  19. The Response ofJournal of bacteriology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sujata S ChaudhariCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Minji KimCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Shulei LeiDepartment of Chemistry, University of Nebraska, Lincoln, Lincoln, Nebraska, USA.
Fareha RazviCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Abdulelah A AlqarzaeeCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Elizabeth H HutflessCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Robert PowersDepartment of Chemistry, University of Nebraska, Lincoln, Lincoln, Nebraska, USA.
Matthew C ZimmermanCellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Paul D FeyCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Vinai C ThomasCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA vinai.thomas@unmc.edu.ORCID 0000-0002-7886-0727
University of Nebraska Medical Center · USUniversity of Nebraska–Lincoln · US

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAYLES, KENNETH W. · 2009 to 2023
$32.1M
Redox Biology CenterP30GM103335 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI BECKER, DONALD F · 2012 to 2016
$4.3M
NIAID NIH HHS P01 AI083211NIGMS NIH HHS P30 GM103335
6 · The paper itself

Abstract

Macrophage-derived nitric oxide (NO·) is a crucial effector against invading pathogens. Yet, paradoxically, several bacterial species, including some pathogens, are known to endogenously produce NO· via nitric oxide synthase (NOS) activity, despite its apparent cytotoxicity. Here, we reveal a conserved role for bacterial NOS in activating aerobic respiration. We demonstrate that nitrite generated from endogenous NO· decomposition stimulates quinol oxidase activity in

Indexed as

AerobiosisBacterial ProteinsElectron Transport Complex IVMutationNitric OxideNitric Oxide SynthaseNitritesOxidation-ReductionOxidative StressOxidoreductasesRepressor ProteinsStaphylococcus aureusBacterial Proteinscytochrome o oxidaseduroquinol oxidaseElectron Transport Complex IVNitric OxideNitric Oxide SynthaseNitritesOxidoreductasesRepressor ProteinsSrrB protein, Staphyolococcus aureuscytochrome bo oxidasenitric oxide synthasenitritequinol oxidaserespirationStaphylococcus aureusTCA cycle

Identifiers

PMID28765220
PMCPMC5539425
OpenAlexW2740950176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.