Evidence map›Paper›PMID 28765164›Full record

ArticleThe EMBO journal2017

Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.

Leila Touat-Todeschini, Yuichi Shichino, Mathieu Dangin, Nicolas Thierry-Mieg, Benoit Gilquin, Edwige Hiriart, Ravi Sachidanandam, Emeline Lambert, Janine Brettschneider, Michael Reuter and 5 more

Abstract read
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
  2. Review
  3. Fungi as models of centromere innovation: from DNA sequence to 3-dimensional arrangement.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Long RNA-Mediated Chromatin Regulation in Fission Yeast and Mammals.International journal of molecular sciences · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Leila Touat-TodeschiniInstitut for Advanced Biosciences, UMR InsermU1209/CNRS5309/UGA, University of Grenoble Alpes, Grenoble, France.
Yuichi ShichinoLaboratory of Cell Responses, National Institute for Basic Biology, Okazaki, Aichi, Japan.ORCID 0000-0002-0093-1185
Mathieu DanginInstitut for Advanced Biosciences, UMR InsermU1209/CNRS5309/UGA, University of Grenoble Alpes, Grenoble, France.
Nicolas Thierry-MiegTIMC-IMAG, University of Grenoble Alpes, Grenoble, France.
Benoit GilquinCEA, LETI, CLINATEC, MINATEC Campus, University of Grenoble Alpes, Grenoble, France.
Edwige HiriartInstitut for Advanced Biosciences, UMR InsermU1209/CNRS5309/UGA, University of Grenoble Alpes, Grenoble, France.
Ravi SachidanandamDepartment of Oncological Sciences, Icahn School of Medicine at Sinai, New York, NY, USA.ORCID 0000-0001-9844-4459
Emeline LambertInstitut for Advanced Biosciences, UMR InsermU1209/CNRS5309/UGA, University of Grenoble Alpes, Grenoble, France.
Janine BrettschneiderEuropean Molecular Biology Laboratory, Grenoble Outstation, University of Grenoble Alpes-EMBL-CNRS, Grenoble, France.
Michael ReuterEuropean Molecular Biology Laboratory, Grenoble Outstation, University of Grenoble Alpes-EMBL-CNRS, Grenoble, France.
Jan KadlecEuropean Molecular Biology Laboratory, Grenoble Outstation, University of Grenoble Alpes-EMBL-CNRS, Grenoble, France.
Ramesh PillaiInstitut de Biologie Structurale (IBS), CEA, CNRS, Université Grenoble Alpes, Grenoble, France.
Akira YamashitaLaboratory of Cell Responses, National Institute for Basic Biology, Okazaki, Aichi, Japan.
Masayuki YamamotoLaboratory of Cell Responses, National Institute for Basic Biology, Okazaki, Aichi, Japan.
André VerdelInstitut for Advanced Biosciences, UMR InsermU1209/CNRS5309/UGA, University of Grenoble Alpes, Grenoble, France andre.verdel@univ-grenoble-alpes.fr.ORCID 0000-0001-6048-3794

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) regulating gene expression at the chromatin level are widespread among eukaryotes. However, their functions and the mechanisms by which they act are not fully understood. Here, we identify new fission yeast regulatory lncRNAs that are targeted, at their site of transcription, by the YTH domain of the RNA-binding protein Mmi1 and degraded by the nuclear exosome. We uncover that one of them,

Indexed as

Gene SilencingGene Expression Regulation, FungalHeterochromatinRNA, Long NoncodingSchizosaccharomycesSchizosaccharomyces pombe ProteinsHeterochromatinRNA, Long NoncodingSchizosaccharomyces pombe Proteinsheterochromatinnon‐coding RNA (ncRNA)sexual differentiationtranscriptionYTH domain

Identifiers

PMID28765164
PMCPMC5579383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.