Evidence map›Paper›PMID 28765159›Full record

ArticleGenes & development2017

The power of the few.

Ran Chen, Yuan Pan, David H Gutmann

Abstract readComment
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Drug Conjugates for Targeting Eph Receptors in Glioblastoma.Pharmaceuticals (Basel, Switzerland) · 2020
    Article
  4. Article
  5. EGFRJournal of oncology · 2019
    Review
  6. Receptor-Targeted Glial Brain Tumor Therapies.International journal of molecular sciences · 2018
    Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Ran ChenDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Yuan PanDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
David H GutmannDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Funding

Defining the Mechanistic Basis for Neurofibromatosis-1 Nervous System Disease HeterogeneityR35NS097211 · NINDS · WASHINGTON UNIVERSITY · PI GUTMANN, DAVID H · 2017 to 2024
$5.7M
NINDS NIH HHS R35 NS097211
6 · The paper itself

Abstract

Converging evidence from numerous laboratories has revealed that malignant brain cancers are complex ecological systems composed of distinct cellular and acellular elements that collectively dictate glioblastoma biology. Our understanding of the individual contributions of each of these components is vital to the design of effective therapies against these cancers. In this issue of

Indexed as

Brain NeoplasmsErbB ReceptorsGene Expression Regulation, NeoplasticGlioblastomaHumansMolecular Targeted TherapyMutationErbB ReceptorsEGFRglioblastomaIL-6NF-κBsurvivintumor heterogeneity

Identifiers

PMID28765159
PMCPMC5558920

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.