ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2017
Effect of tobacco smoking on frontal cortical thickness development: A longitudinal study in a mixed cohort of ADHD-affected and -unaffected youth.
Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The Influence of Cannabis and Nicotine Co-use on Neuromaturation: A Systematic Review of Adolescent and Young Adult Studies.Biological psychiatry · 2021Pooled it
- Environmental Exposures and Neuroimaging in Children with Neurodevelopmental Disorders: A Scoping Review.Current environmental health reports · 2026Article
- Article
- Buprenorphine and Surface-based Brain Morphometry: Impacts on Cortical Thickness, Depth, and Gyrification in Patients with Opioid Use Disorder.Indian journal of psychological medicine · 2025Article
- Adolescent substance use initiation and long-term neurobiological outcomes: insights, challenges and opportunities.Molecular psychiatry · 2024Review
- Correlation between frailty and reduction in cortical thickness in patients with chronic obstructive pulmonary disease.Scientific reports · 2024Article
- The Combined Effects of Nicotine and Cannabis on Cortical Thickness Estimates in Adolescents and Emerging Adults.Brain sciences · 2024Article
- Use of Tobacco Products and Suicide Attempts Among Elementary School-Aged Children.JAMA network open · 2024Article
- The effects of nicotine use during adolescence and young adulthood on gray matter cerebral blood flow estimates.Brain imaging and behavior · 2024Article
- Investigating the Relationship Between Smoking Behavior and Global Brain Volume.Biological psychiatry global open science · 2024Article
- Nicotine use during late adolescence and young adulthood is associated with changes in hippocampal volume and memory performance.Frontiers in neuroscience · 2024Article
- The association between attention deficit hyperactivity disorder (ADHD) and smoking experience or exposure to environmental tobacco smoke among children and adolescents.Tobacco induced diseases · 2023Article
- Longitudinal Assessments of Neurocognitive Performance and Brain Structure Associated With Initiation of Tobacco Use in Children, 2016 to 2021.JAMA network open · 2022Observational
- A Multi-Modal MRI Analysis of Cortical Structure in Relation to Gender Dysphoria, Sexual Orientation, and Age in Adolescents.Journal of clinical medicine · 2021Article
- The associations of comorbid substance use disorders and psychiatric conditions with adolescent brain structure and function: A review.Journal of the neurological sciences · 2020Review
- Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates.Frontiers in human neuroscience · 2020Article
- The impact of local regulation on reasons for electronic cigarette use among Southern California young adults.Addictive behaviors · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Smoking rates are particularly high during adolescence and young adulthood, when the brain is still undergoing significant developmental changes. Cross-sectional studies have revealed altered brain structure in smokers, such as thinner frontal cortical areas. Attention-deficit/hyperactivity disorder (ADHD) increases the risk of becoming nicotine-dependent, and has also been associated with abnormalities in frontal gray matter structure. The present study examines the relationships between smoking, cortical thickness and ADHD symptoms in a longitudinal design that compares adolescent and young adult smokers (n=44; 35 ADHD-affected) and non-smokers (n=45; 32 ADHD-affected) on frontal cortical thickness. Average frontal cortical thickness was estimated through structural magnetic resonance imaging (MRI) at two time points (mean ages 17.7 and 21.1 years), on average 3.4 years apart. Smokers had a 2.6% thinner frontal cortex than non-smokers and this difference was not explained by ADHD or other confounding factors. The rate of cortical thinning across the 3.4-year MRI measurement interval was similar in the total group of smokers compared to non-smokers. However, speeded thinning did occur in smokers who had started regular smoking more recently, in between the two measurements. These novel regular smokers did not differ significantly from the non-smokers at baseline. This suggests that the thinner frontal cortex was not a predisposing factor but rather a consequence of smoking. Although smokers had more ADHD symptoms overall, smoking did not influence the developmental course of ADHD symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.