Evidence map›Paper›PMID 28764778›Full record

ArticleBMC complementary and alternative medicine2017

Centella asiatica modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC's).

Dhaneshree Bestinee Naidoo, Anil Amichund Chuturgoon, Alisa Phulukdaree, Kanive Parashiva Guruprasad, Kapaettu Satyamoorthy, Vikash Sewram

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. In Vitro Cytotoxic Activity of African Plants: A Review.Molecules (Basel, Switzerland) · 2022
    Review
  4. Phytochemical profile andAfrican health sciences · 2021
    Article
  5. Therapeutic Potential ofFrontiers in pharmacology · 2020
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Dhaneshree Bestinee NaidooDiscipline of Medical Biochemistry, Faculty of Health Sciences, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4013, South Africa.
Anil Amichund ChuturgoonDiscipline of Medical Biochemistry, Faculty of Health Sciences, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4013, South Africa.
Alisa PhulukdareeDiscipline of Medical Biochemistry, Faculty of Health Sciences, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4013, South Africa.
Kanive Parashiva GuruprasadDivision of Biotechnology, School of Life Sciences, Manipal University, Planetarium Complex, Manipal, Karnataka, 576 104, India.
Kapaettu SatyamoorthyDivision of Biotechnology, School of Life Sciences, Manipal University, Planetarium Complex, Manipal, Karnataka, 576 104, India.
Vikash SewramAfrican Cancer Institute, Faculty of Medicine and Health Sciences, Stellenbosch University, P.O. Box 241, Cape Town, 8000, South Africa. vsewram@sun.ac.za.ORCID http://orcid.org/0000-0002-4547-7270
University of KwaZulu-Natal · ZAManipal Academy of Higher Education · INWestern Cape Department of Health · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer cachexia is associated with increased pro-inflammatory cytokine levels. Centella asiatica (C. asiatica) possesses antioxidant, anti-inflammatory and anti-tumour potential. We investigated the modulation of antioxidants, cytokines and cell death by C. asiatica ethanolic leaf extract (C

methodsCytotoxcity of C

resultsC

conclusionIn PBMC's and THP-1 cells, C

Indexed as

CachexiaCell DeathCentellaNeoplasmsAdenosine TriphosphateAnti-Inflammatory AgentsAntioxidantsCaspasesCell LineCell SurvivalCytokinesHumansInflammationLeukocytesLeukocytes, MononuclearOxidantsAdenosine TriphosphateAnti-Inflammatory AgentsAntioxidantsCaspasesCentella asiatica extractCytokinesOxidantsPlant ExtractsTriterpenesApoptosisCachexiaCancerCentella asiaticaCytokines

Identifiers

PMID28764778
PMCPMC5540453
OpenAlexW4236979624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.