Evidence map›Paper›PMID 28764773›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2017

Quantification of both the area-at-risk and acute myocardial infarct size in ST-segment elevation myocardial infarction using T1-mapping.

Heerajnarain Bulluck, Matthew Hammond-Haley, Marianna Fontana, Daniel S Knight, Alex Sirker, Anna S Herrey, Charlotte Manisty, Peter Kellman, James C Moon, Derek J Hausenloy

Registry-linked trialOpen access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06029400 (CT-based Myocardial Characterization), which is not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06029400 recruitingnot on this mapstarted 2020, after this paper: background citation

CT-based Myocardial Characterization

TypeobservationalSponsorIRCCS San RaffaeleRan2020 to 2032Enrolled2,200ConditionsCardiovascular Diseases
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. CircMACF1 Attenuates Acute Myocardial Infarction Through miR-500b-5p-EMP1 Axis.Journal of cardiovascular translational research · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. COPD and acute myocardial infarction.European respiratory review : an official journal of the European Respiratory Society · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Heerajnarain BulluckThe Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK. h.bulluck@gmail.com.ORCID http://orcid.org/0000-0002-1985-1783
Matthew Hammond-HaleyThe Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK.
Marianna FontanaNational Amyloidosis Centre, University College London, Royal Free Hospital, London, UK.
Daniel S KnightNational Amyloidosis Centre, University College London, Royal Free Hospital, London, UK.
Alex SirkerThe National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK.
Anna S HerreyBarts Heart Centre, St Bartholomew's Hospital, London, UK.
Charlotte ManistyBarts Heart Centre, St Bartholomew's Hospital, London, UK.
Peter KellmanNational Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, USA.
James C MoonThe National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK.
Derek J HausenloyThe Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK.
St Bartholomew's Hospital · GBThe Royal Free Hospital · GBCardiovascular Institute of the South · USNational Institutes of Health · USUniversity College London · GB

Funding

British Heart Foundation CS/14/3/31002British Heart Foundation FS/10/039/28270British Heart Foundation FS/10/72/28568
6 · The paper itself

Abstract

backgroundA comprehensive cardiovascular magnetic resonance (CMR) in reperfused ST-segment myocardial infarction (STEMI) patients can be challenging to perform and can be time-consuming. We aimed to investigate whether native T1-mapping can accurately delineate the edema-based area-at-risk (AAR) and post-contrast T1-mapping and synthetic late gadolinium (LGE) images can quantify MI size at 1.5 T. Conventional LGE imaging and T2-mapping could then be omitted, thereby shortening the scan duration.

methodsTwenty-eight STEMI patients underwent a CMR scan at 1.5 T, 3 ± 1 days following primary percutaneous coronary intervention. The AAR was quantified using both native T1 and T2-mapping. MI size was quantified using conventional LGE, post-contrast T1-mapping and synthetic magnitude-reconstructed inversion recovery (MagIR) LGE and synthetic phase-sensitive inversion recovery (PSIR) LGE, derived from the post-contrast T1 maps.

resultsNative T1-mapping performed as well as T2-mapping in delineating the AAR (41.6 ± 11.9% of the left ventricle [% LV] versus 41.7 ± 12.2% LV, P = 0.72; R

conclusionsT1-mapping can accurately quantify both the edema-based AAR (using native T1 maps) and acute MI size (using post-contrast T1 maps) in STEMI patients without major cardiovascular risk factors. This approach would shorten the duration of a comprehensive CMR study without significantly compromising on data acquisition and would obviate the need to perform T2 maps and LGE imaging.

Indexed as

AdultAgedContrast MediaEdema, CardiacFemaleHumansMagnetic Resonance Imaging, CineMaleMeglumineMiddle AgedMyocardiumObserver VariationOrganometallic CompoundsPercutaneous Coronary InterventionPredictive Value of TestsReproducibility of ResultsContrast Mediagadoterate meglumineMeglumineOrganometallic CompoundsArea-at-riskCardiovascular magnetic resonanceMyocardial infarct sizePrimary percutaneous coronary interventionST-segment elevation myocardial infarctionT1-mappingT2-mapping

Identifiers

PMID28764773
PMCPMC5539889
OpenAlexW2739960479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.