Evidence map›Paper›PMID 28764771›Full record

ArticleAlzheimer's research & therapy2017

Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer's disease.

Emilie T Reas, Donald J Hagler, Nathan S White, Joshua M Kuperman, Hauke Bartsch, Karalani Cross, Richard Q Loi, Akshara R Balachandra, M J Meloy, Christina E Wierenga and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Emilie T ReasDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA. ereas@ucsd.edu.
Donald J HaglerDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Nathan S WhiteDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Joshua M KupermanDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Hauke BartschCenter for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.
Karalani CrossDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Richard Q LoiCenter for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.
Akshara R BalachandraCenter for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.
M J MeloyDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Christina E WierengaDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Douglas GalaskoDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
James B BrewerDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Anders M DaleDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Linda K McEvoyDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
University of California, San Diego · USVA San Diego Healthcare System · US

Funding

VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALASKO, DOUGLAS R · 1985 to 2018
$55.4M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
Cognitive and Brain Changes in Preclinical Alzheimer's DiseaseI01CX000565 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI WIERENGA, CHRISTINA E · 2013 to 2022
–
CSRD VA I01 CX000565NIA NIH HHS P50 AG005131NIA NIH HHS R01 AG022381
6 · The paper itself

Abstract

backgroundDiffusion imaging has demonstrated sensitivity to structural brain changes in Alzheimer's disease (AD). However, there remains a need for a more complete characterization of microstructural alterations occurring at the earliest disease stages, and how these changes relate to underlying neuropathology. This study evaluated the sensitivity of restriction spectrum imaging (RSI), an advanced diffusion magnetic resonance imaging (MRI) technique, to microstructural brain changes in mild cognitive impairment (MCI) and AD.

methodsMRI and neuropsychological test data were acquired from 31 healthy controls, 12 individuals with MCI, and 13 individuals with mild AD, aged 63-93 years. Cerebrospinal fluid amyloid-β levels were measured in a subset (n = 38) of participants. RSI measures of neurite density (ND) and isotropic free water (IF) were computed in fiber tracts and in hippocampal and entorhinal cortex gray matter, respectively. Analyses evaluated whether these measures predicted memory performance, correlated with amyloid-β levels, and distinguished impaired individuals from controls. For comparison, analyses were repeated with standard diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA) and mean diffusivity.

resultsBoth RSI and DTI measures correlated with episodic memory and disease severity. RSI, but not DTI, measures correlated with amyloid-β42 levels. ND and FA in the arcuate fasciculus and entorhinal cortex IF most strongly predicted recall performance. RSI measures of arcuate fasciculus ND and entorhinal cortex IF best discriminated memory impaired participants from healthy participants.

conclusionsRSI is highly sensitive to microstructural changes in the early stages of AD, and is associated with biochemical markers of AD pathology. Reduced ND in cortical association fibers and increased medial temporal lobe free-water diffusion predicted episodic memory, distinguished cognitively impaired from healthy individuals, and correlated with amyloid-β. Although further research is needed to assess the sensitivity of RSI to preclinical AD and disease progression, these results suggest that RSI may be a promising tool to better understand neuroanatomical changes in AD and their association with neuropathology.

Indexed as

Diffusion Tensor ImagingAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAnisotropyBrainFemaleHumansImage Processing, Computer-AssistedMaleMemory DisordersMiddle AgedNeuropsychological TestsPeptide FragmentsPsychiatric Status Rating ScalesAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)Peptide FragmentsAlzheimer’s diseaseAmyloidDementiaDiffusion imagingMemoryMild cognitive impairmentMRI

Identifiers

PMID28764771
PMCPMC5539622
OpenAlexW2741829806

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.