ArticleProceedings of the National Academy of Sciences of the United States of America1986
Genetic linkage between the antigenic group (Ag) variation and the apolipoprotein B gene: assignment of the Ag locus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Association between the APOB XbaI and EcoRI polymorphisms and lipids in Chinese: a meta-analysis.Lipids in health and disease · 2015Pooled it
- Article
- A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.Genome research · 2001Article
- Polymorphisms in the apolipoprotein B-100 gene contributes to normal variation in plasma lipids in 464 Danish men born in 1948.Human genetics · 1993Article
- The polymorphism ApoB/4311 in patients with myocardial infarction and controls: the ECTIM Study.Human genetics · 1992Article
- Two amino acid substitutions in apolipoprotein B are in complete allelic association with the antigen group (x/y) polymorphism: evidence for little recombination in the 3' end of the human gene.American journal of human genetics · 1992Article
- Molecular and metabolic basis for the metabolic disorder normotriglyceridemic abetalipoproteinemia.The Journal of clinical investigation · 1991Article
- Genetic structure and the search for genotype-phenotype relationships: an example from disequilibrium in the Apo B gene region.Genetics · 1991Article
- Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".Human genetics · 1990Review
- A worldwide population study of the Ag-system haplotypes, a genetic polymorphism of human low-density lipoprotein.American journal of human genetics · 1990Article
- Article
- Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Relationships between DNA and protein polymorphisms of apolipoprotein B.Human genetics · 1988Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antigenic group (Ag) system of homospecific human serum antigens of low density lipoprotein is detected by antiserum from multiply transfused patients. A complex series of common Ag alleles has been described, but the biochemical nature of this polymorphism is uncertain. Here we report that DNA polymorphisms at the human apolipoprotein B (apoB) locus are very closely linked to alleles of the Ag system. We also show a strong association between Ag(x) and a polymorphism detected with the restriction endonuclease Xba I. We conclude that the immunologically determined Ag system represents protein polymorphism of apoB rather than primary genetic differences in posttranslational processing or lipid binding. These studies therefore demonstrate that the Ag locus is located on the short arm of human chromosome 2 in the region p23-p24 to which the apoB gene has been assigned. Since the Ag(x) antigen is associated with altered plasma lipid levels, this determinant may indicate a functionally important domain of apoB.
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