ArticleScience immunology2017
The metabolic regulator mTORC1 controls terminal myeloid differentiation.
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In one paragraph
Article in Science immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Distinct sensing of BCAAs by mTOR and c-Myc governs T cell proliferation, independent of catabolism.bioRxiv : the preprint server for biology · 2026Article
- Gut Metabolite Indole-3-Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging-Related Myocardial Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- mTOR Signaling in Macrophages: All Depends on the Context.International journal of molecular sciences · 2025Review
- Article
- Aberrant monocytopoiesis drives granuloma development in sarcoidosis.International immunology · 2024Article
- Altered lipid homeostasis and autophagy precipitate diffuse alveolar hemorrhage in murine lupus.Autophagy reports · 2024Article
- Mechanistic target of rapamycin in regulating macrophage function in inflammatory cardiovascular diseases.Journal of molecular and cellular cardiology · 2024Review
- Reprogramming tumor-associated macrophages to outcompete endovascular endothelial progenitor cells and suppress tumor neoangiogenesis.Immunity · 2023Article
- At the Heart of Treating Kawasaki Disease: The Search for New Approaches to Prevent Coronary Artery Aneurysms.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophagesFrontiers in immunology · 2023Article
- NOD2 in monocytes negatively regulates macrophage development through TNFalpha.Frontiers in immunology · 2023Article
- mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome.Nature communications · 2022Article
- Article
- TLR or NOD receptor signaling skews monocyte fate decision via distinct mechanisms driven by mTOR and miR-155.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- Article
- High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage.JCI insight · 2019Article
- Cas9eLife · 2019Article
- Can Metabolic Pathways Be Therapeutic Targets in Rheumatoid Arthritis?Journal of clinical medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Pui Y LeeDivision of Immunology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID http://orcid.org/0000-0002-5779-4193
David B SykesCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID http://orcid.org/0000-0002-9788-0221
Sarah AmeriDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID http://orcid.org/0000-0002-9565-5047
Demetrios KalaitzidisCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Julia F CharlesDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
Nathan Nelson-ManeyDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID http://orcid.org/0000-0003-3939-8557
Kevin WeiDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
Pierre CuninDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
Allyn MorrisDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID http://orcid.org/0000-0002-1932-6444
Astrid E CardonaDepartment of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID http://orcid.org/0000-0002-5093-8078
David E RootBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
David T ScaddenCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.ORCID http://orcid.org/0000-0001-9821-7133
Peter A NigrovicDivision of Immunology, Boston Children's Hospital, Boston, MA 02115, USA. pnigrovic@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-2126-3702
Funding
Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEONARD Ira ZON · 2017 to 2026
$24.6MMOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1MMECHANISMS OF ARTHRITIC &DERMATOLOGY DISORDERST32AR007530 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B. Brenner, Ellen M Gravallese · 1986 to 2026
$10.4MJoint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4MLy6 family members in neutrophil biologyR01AR065538 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2014 to 2024
$4.0MRole of CX3CR1 in adaptive immunity during autoimmune encephalomyelitisSC1GM095426 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI CARDONA, ASTRID E · 2012 to 2016
$1.5MC5a receptor on mast cells in inflammatory arthritisK08AR051321 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2006 to 2010
$643kOsteoclast precursors in bone homeostasis and inflammatory arthritisK08AR062590 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CHARLES, JULIA F · 2012 to 2016
$619kmTOR Complexes in HematopoiesisK01DK092300 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KALAITZIDIS, DEMETRIOS · 2011 to 2015
$601kNHLBI NIH HHS P01 HL131477NIAID NIH HHS T32 AI007512NIAMS NIH HHS K08 AR051321NIAMS NIH HHS K08 AR062590NIAMS NIH HHS P30 AR070253NIAMS NIH HHS R01 AR065538NIAMS NIH HHS T32 AR007530NIDDK NIH HHS K01 DK092300NIGMS NIH HHS SC1 GM095426
Abstract
Monocytes are derived from hematopoietic stem cells through a series of intermediate progenitor stages, but the factors that regulate this process are incompletely defined. Using a Ccr2/Cx
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.