Observational studyPloS one2017
The delta neutrophil index is a prognostic factor for postoperative mortality in patients with sepsis caused by peritonitis.
Observational study in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 43 citations in OpenAlex.
- The Role of the Delta Neutrophil Index in Determining the Severity of Intrahepatic Cholestasis of Pregnancy.Saudi medical journal · 2026Article
- Prognostic and Diagnostic Power of Delta Neutrophil Index and Mean Platelet Component in Febrile Patients with Suspected Sepsis.Biomedicines · 2023Article
- Biomarkers to predict mortality in patients with Fournier's gangrene admitted to the intensive care unit after surgery in South Korea.Acute and critical care · 2023Article
- Explainable machine learning using perioperative serial laboratory results to predict postoperative mortality in patients with peritonitis-induced sepsis.Annals of surgical treatment and research · 2023Article
- Adjuvant intravenous immunoglobulin administration on postoperative critically ill patients with secondary peritonitis: a retrospective study.Acute and critical care · 2023Article
- Delta Neutrophil Index for the Prediction of Prognosis in Acute Gastrointestinal Diseases; Diagnostic Test Accuracy Meta-Analysis.Journal of clinical medicine · 2020Article
- Diagnostic Value of Laboratory Parameters for Distinguishing Between Herpes Zoster and Bacterial Superficial Skin and Soft Tissue Infections.Acta dermato-venereologica · 2020Article
- Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis.Mediators of inflammation · 2020Observational
- Delta neutrophil index for predicting mortality in trauma patients who underwent emergent abdominal surgery: A case controlled study.PloS one · 2020Article
- Super-Low Dose Lipopolysaccharide Dysregulates Neutrophil Migratory Decision-Making.Frontiers in immunology · 2019Article
- Assessment of immune organ dysfunction in critical illness: utility of innate immune response markers.Intensive care medicine experimental · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe delta neutrophil index (DNI) represents the fraction of circulating immature granulocytes and is a marker of infection and sepsis. Our objective was to evaluate the usefulness of DNI for predicting in-hospital mortality within 30 days after surgery in patients with sepsis caused by peritonitis by means of comparing DNI, white blood cell (WBC) count, neutrophil percentage, and C-reactive protein (CRP) before and after surgery. MATERIALS AND
methodsWe performed a retrospective analysis of demographic, clinical, and laboratory data. DNI, WBC count, neutrophil percentage, and CRP were measured before surgery, and at 12-36 h (day 1) and 60-84 h (day 3) after surgery.
resultsThere were 116 (73.7%) survivors and 44 (26.3%) non-survivors. The rates of septic shock, norepinephrine administration, renal replacement, mechanical ventilator therapy, and reoperation, the Simplified Acute Physiology Score-3 (SAPS3), and the Sepsis-related Organ Failure Assessment (SOFA) score were greater in non-survivors. DNI on day 3 was better than the other laboratory variables for predicting mortality. DNI was correlated with the SAPS3 (r = .46, p = .00) and SOFA score (r = .45, p = .00). The optimal cut-off DNI for predicting mortality was 7.8% (sensitivity: 77.3%; specificity: 95.9%). In receiver-operating characteristic curve analysis, DNI on day 3 was the best indicator of mortality (area under the curve: .880; 95% confidence interval: .80-.96).
conclusionsOur results indicate that DNI is better than other laboratory variables for predicting postoperative mortality in patients with sepsis caused by peritonitis. DNI > 7.8% on day 3 was a reliable predictor of postoperative mortality.
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