ArticlePloS one2017
Effect of ultrasound frequency on the Nakagami statistics of human liver tissues.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- A Systematized Review of Quantitative Ultrasound Based on First-Order Speckle Statistics.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Pooled it
- Breast tumor diagnosis via multimodal deep learning using ultrasound B-mode and Nakagami images.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Feasibility of Backscattering Coefficient Evaluation of Soft Tissue Using High-Frequency Annular Array Probe.Sensors (Basel, Switzerland) · 2024Article
- The severity of portal hypertension by a non-invasive assessment: acoustic structure quantification analysis of liver parenchyma.BMC medical imaging · 2022Article
- Robust Scatterer Number Density Segmentation of Ultrasound Images.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Imaging the Effects of Whole-Body Vibration on the Progression of Hepatic Steatosis by Quantitative Ultrasound Based on Backscatter Envelope Statistics.Pharmaceutics · 2022Article
- Detection of pediatric hepatic steatosis through ultrasound backscattering analysis.European radiology · 2021Article
- Ultrasound Sample Entropy Imaging: A New Approach for Evaluating Hepatic Steatosis and Fibrosis.IEEE journal of translational engineering in health and medicine · 2021Article
- Clinical Value of Information Entropy Compared with Deep Learning for Ultrasound Grading of Hepatic Steatosis.Entropy (Basel, Switzerland) · 2020Article
- Ultrasound Assessment of Hepatic Steatosis by Using the Double Nakagami Distribution: A Feasibility Study.Diagnostics (Basel, Switzerland) · 2020Article
- Improved evaluation of backscatter characteristics of soft tissue using high-frequency annular array.Japanese journal of applied physics (2008) · 2020Article
- Characterization of limb lymphedema using the statistical analysis of ultrasound backscattering.Quantitative imaging in medicine and surgery · 2020Article
- Hepatic steatosis assessment using ultrasound homodyned-K parametric imaging: the effects of estimators.Quantitative imaging in medicine and surgery · 2019Article
- Ultrasound Entropy Imaging of Nonalcoholic Fatty Liver Disease: Association with Metabolic Syndrome.Entropy (Basel, Switzerland) · 2018Article
- Performance Evaluations on Using Entropy of Ultrasound Log-Compressed Envelope Images for Hepatic Steatosis Assessment: An In Vivo Animal Study.Entropy (Basel, Switzerland) · 2018Article
- Quantitative Ultrasound Assessment of Hepatic Steatosis.Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The analysis of the backscattered statistics using the Nakagami parameter is an emerging ultrasound technique for assessing hepatic steatosis and fibrosis. Previous studies indicated that the echo amplitude distribution of a normal liver follows the Rayleigh distribution (the Nakagami parameter m is close to 1). However, using different frequencies may change the backscattered statistics of normal livers. This study explored the frequency dependence of the backscattered statistics in human livers and then discussed the sources of ultrasound scattering in the liver. A total of 30 healthy participants were enrolled to undergo a standard care ultrasound examination on the liver, which is a natural model containing diffuse and coherent scatterers. The liver of each volunteer was scanned from the right intercostal view to obtain image raw data at different central frequencies ranging from 2 to 3.5 MHz. Phantoms with diffuse scatterers only were also made to perform ultrasound scanning using the same protocol for comparisons with clinical data. The Nakagami parameter-frequency correlation was evaluated using Pearson correlation analysis. The median and interquartile range of the Nakagami parameter obtained from livers was 1.00 (0.98-1.05) for 2 MHz, 0.93 (0.89-0.98) for 2.3 MHz, 0.87 (0.84-0.92) for 2.5 MHz, 0.82 (0.77-0.88) for 3.3 MHz, and 0.81 (0.76-0.88) for 3.5 MHz. The Nakagami parameter decreased with the increasing central frequency (r = -0.67, p < 0.0001). However, the effect of ultrasound frequency on the statistical distribution of the backscattered envelopes was not found in the phantom results (r = -0.147, p = 0.0727). The current results demonstrated that the backscattered statistics of normal livers is frequency-dependent. Moreover, the coherent scatterers may be the primary factor to dominate the frequency dependence of the backscattered statistics in a liver.
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