Evidence map›Paper›PMID 28763357›Full record

ArticleAnesthesia and analgesia2018

Variability in the Use of Protective Mechanical Ventilation During General Anesthesia.

Karim S Ladha, Brian T Bateman, Timothy T Houle, Myrthe A C De Jong, Marcos F Vidal Melo, Krista F Huybrechts, Tobias Kurth, Matthias Eikermann

Registry-linked trialAbstract read
In one paragraph

Article in Anesthesia and analgesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03585348 (Importance of Understanding Provider Variability in the Use of Neuromuscular Blocking Drugs and Reversal Agents), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03585348 completednot on this map

Importance of Understanding Provider Variability in the Use of Neuromuscular Blocking Drugs and Reversal Agents

TypeobservationalSponsorBeth Israel Deaconess Medical CenterRan2018 to 2021Enrolled265,537ConditionsNeuromuscular Blockade, Residual Curarisation, Postoperative, Surgery Under General AnaesthesiaArmsNeuromuscular blocking agents
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karim S LadhaFrom the Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Brian T BatemanFrom the Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Timothy T HouleFrom the Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Myrthe A C De JongFrom the Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Marcos F Vidal MeloFrom the Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Krista F HuybrechtsDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Tobias KurthInstitute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Matthias EikermannFrom the Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Funding

Improved methods to assess the comparative safety of new psychiatric medicationsK01MH099141 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI HUYBRECHTS, KRISTA F · 2013 to 2017
$882k
Comparative safety & effectiveness of antihypertensive medications in pregnancyK08HD075831 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BATEMAN, BRIAN THOMAS · 2013 to 2017
$717k
Intraoperative Protective Ventilation and Postoperative Pulmonary ComplicationsR34HL123438 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI VIDAL MELO, MARCOS F · 2015 to 2017
$599k
NHLBI NIH HHS R34 HL123438NICHD NIH HHS K08 HD075831NIMH NIH HHS K01 MH099141
6 · The paper itself

Abstract

backgroundThe purpose of this study was to determine whether significant variation exists in the use of protective ventilation across individual anesthesia providers and whether this difference can be explained by patient, procedure, and provider-related characteristics.

methodsThe cohort consisted of 262 anesthesia providers treating 57,372 patients at a tertiary care hospital between 2007 and 2014. Protective ventilation was defined as a median positive end-expiratory pressure of 5 cm H2O or more, tidal volume of <10 mL/kg of predicted body weight and plateau pressure of <30 cm H2O. Analysis was performed using mixed-effects logistic regression models with propensity scores to adjust for covariates. The definition of protective ventilation was modified in sensitivity analyses.

resultsIn unadjusted analysis, the mean probability of administering protective ventilation was 53.8% (2.5th percentile of provider 19.9%, 97.5th percentile 80.8%). After adjustment for a large number of covariates, there was little change in the results with a mean probability of 51.1% (2.5th percentile 24.7%, 97.5th percentile 77.2%). The variations persisted when the thresholds for protective ventilation were changed.

conclusionsThere was significant variability across individual anesthesia providers in the use of intraoperative protective mechanical ventilation. Our data suggest that this variability is highly driven by individual preference, rather than patient, procedure, or provider-related characteristics.

Indexed as

AnesthesiologistsAdultAgedAnesthesia, GeneralCohort StudiesFemaleHumansIntraoperative CareMaleMiddle AgedPositive-Pressure RespirationProspective StudiesRegistriesRespiration, ArtificialTidal Volume

Identifiers

PMID28763357
PMCPMC6696999

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.