Evidence map›Paper›PMID 28763100›Full record

ArticleClinical and experimental immunology2017

Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism.

B R Brown, E J Lee, P E Snow, E E Vance, Y Iwakura, N Ohno, N Miura, X Lin, G D Brown, C A Wells and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. CARD9 Signaling, Inflammation, and Diseases.Frontiers in immunology · 2022
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Immune Privilege: The Microbiome and Uveitis.Frontiers in immunology · 2020
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

B R BrownVA Portland Health Care System, Portland, OR, USA.
E J LeeVA Portland Health Care System, Portland, OR, USA.
P E SnowVA Portland Health Care System, Portland, OR, USA.
E E VanceVA Portland Health Care System, Portland, OR, USA.
Y IwakuraResearch Institute for Biomedical Sciences, Tokyo University of Science, Tokyo, Japan.
N OhnoTokyo University of Pharmacy and Life Science, Tokyo, Japan.
N MiuraTokyo University of Pharmacy and Life Science, Tokyo, Japan.
X LinDepartment of Molecular and Cellular Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
G D BrownAberdeen Fungal Group, MRC Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
C A WellsThe University of Melbourne Centre for Stem Cell Systems, University of Melbourne, Parkville, Victoria, Australia.
J R SmithEye and Vision Health, Flinders University School of Medicine, Adelaide, Australia.
R R CaspiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
H L RosenzweigVA Portland Health Care System, Portland, OR, USA.ORCID 0000-0002-5636-1134
Oregon Health & Science University · USTokyo University of Pharmacy and Life Sciences · JPFlinders University · AUNational Institutes of Health · USThe University of Melbourne · AUThe University of Texas MD Anderson Cancer Center · USTokyo University of Science · JPUniversity of Aberdeen · GBVA Portland Health Care System · US

Funding

T-CELL LINES AND CLONES IN UVEITAZ01EY000184 · NEI · NATIONAL EYE INSTITUTE · PI CASPI, RACHEL R. · 1985 to 2008
$6.6M
Innate Immunity and its integration in Autoimmune Disease of the EyeR01EY025250 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROSENZWEIG, HOLLY LALLMAN · 2015 to 2023
$2.7M
NOD2 and UveitisR01EY019020 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROSENZWEIG, HOLLY LALLMAN · 2009 to 2012
$1.5M
Interaction of environment and genetics in the predisposition to inflammatory artI01BX002180 · VA · PORTLAND VA MEDICAL CENTER · PI ROSENZWEIG, HOLLY LALLMAN · 2014 to 2021
–
BLRD VA I01 BX002180Intramural NIH HHS Z01 EY000184Medical Research Council MR/N006364/1NEI NIH HHS R01 EY019020NEI NIH HHS R01 EY025250
6 · The paper itself

Abstract

Uveitis (intraocular inflammation) is a leading cause of loss of vision. Although its aetiology is largely speculative, it is thought to arise from complex genetic-environmental interactions that break immune tolerance to generate eye-specific autoreactive T cells. Experimental autoimmune uveitis (EAU), induced by immunization with the ocular antigen, interphotoreceptor retinoid binding protein (IRBP), in combination with mycobacteria-containing complete Freund's adjuvant (CFA), has many clinical and histopathological features of human posterior uveitis. Studies in EAU have focused on defining pathogenic CD4

Indexed as

AnimalsAutoimmune DiseasesCandida albicansCandidiasisCARD Signaling Adaptor ProteinsEye ProteinsLectins, C-TypeMiceMice, Mutant StrainsRetinol-Binding ProteinsRetinol-Binding Proteins, InterstitialSaccharomyces cerevisiaeTh17 CellsUveitisCard9 protein, mouseCARD Signaling Adaptor Proteinsdectin-2, mouseEye ProteinsLectins, C-TypeRetinol-Binding ProteinsRetinol-Binding Proteins, Interstitialautoimmunityeyeinflammationrodentuveitis

Identifiers

PMID28763100
PMCPMC5680064
OpenAlexW2739849654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.