Evidence map›Paper›PMID 28763009›Full record

ArticleBiomolecules2017

Metal Binding Properties of the N-Terminus of the Functional Amyloid Orb2.

Thalia H Bajakian, Silvia A Cervantes, Maria A Soria, Maïwenn Beaugrand, Ji Yun Kim, Rachel J Service, Ansgar B Siemer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. A new era for understanding amyloid structures and disease.Nature reviews. Molecular cell biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Thalia H BajakianDepartment of Biochemistry & Molecular Medicine and the Zilkha Neurogenetic Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA. t.bajakian@gmail.com.
Silvia A CervantesDepartment of Biochemistry & Molecular Medicine and the Zilkha Neurogenetic Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA. angie.crvts@gmail.com.
Maria A SoriaDepartment of Biochemistry & Molecular Medicine and the Zilkha Neurogenetic Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA. mariaaco@usc.edu.
Maïwenn BeaugrandDepartment of Biochemistry & Molecular Medicine and the Zilkha Neurogenetic Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA. maiwenn.beaugrand@gmail.com.
Ji Yun KimDepartment of Biochemistry & Molecular Medicine and the Zilkha Neurogenetic Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA. kim821@usc.edu.
Rachel J ServiceDepartment of Biochemistry & Molecular Medicine and the Zilkha Neurogenetic Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA. servicerj@gmail.com.
Ansgar B SiemerDepartment of Biochemistry & Molecular Medicine and the Zilkha Neurogenetic Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA. asiemer@usc.edu.
McGill University · CAUnited States Department of the Army · US

Funding

Molecular mechanisms of huntingtin misfoldingR01NS084345 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LANGEN, RALF · 2015 to 2019
$2.2M
Orb2 a functional amyloid in long-term memory: Its structure and how it formsR01GM110521 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SIEMER, ANSGAR B · 2015 to 2019
$1.9M
CIHRNIGMS NIH HHS R01 GM110521NINDS NIH HHS R01 NS084345
6 · The paper itself

Abstract

The cytoplasmic polyadenylation element binding protein (CPEB) homologue Orb2 is a functional amyloid that plays a key regulatory role for long-term memory in

Indexed as

AnimalsBinding SitesCalorimetryCircular DichroismDrosophila melanogasterDrosophila ProteinsGlutamineHistidineMicroscopy, ElectronmRNA Cleavage and Polyadenylation FactorsMutagenesis, Site-DirectedNickelProtein BindingTranscription FactorsDrosophila ProteinsGlutamineHistidinemRNA Cleavage and Polyadenylation FactorsNickelOrb2 protein, DrosophilaTranscription FactorsaggregationamyloidITCprotein–metal interactionthioflavin T fluorescence

Identifiers

PMID28763009
PMCPMC5618238
OpenAlexW2741029033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.