Evidence map›Paper›PMID 28762881›Full record

ArticleTissue engineering. Part C, Methods2017

Porcine Ischemic Wound-Healing Model for Preclinical Testing of Degradable Biomaterials.

Prarthana Patil, John R Martin, Samantha M Sarett, Alonda C Pollins, Nancy L Cardwell, Jeffrey M Davidson, Scott A Guelcher, Lillian B Nanney, Craig L Duvall

Abstract read
In one paragraph

Article in Tissue engineering. Part C, Methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Exploring New Horizons in Wound Healing: A Comprehensive Analysis.Recent advances in inflammation & allergy drug discovery · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Prarthana Patil1 Department of Biomedical Engineering, Vanderbilt University , Nashville, Tennessee.
John R Martin1 Department of Biomedical Engineering, Vanderbilt University , Nashville, Tennessee.
Samantha M Sarett1 Department of Biomedical Engineering, Vanderbilt University , Nashville, Tennessee.
Alonda C Pollins2 Department of Plastic Surgery, Vanderbilt University Medical Center , Nashville, Tennessee.
Nancy L Cardwell2 Department of Plastic Surgery, Vanderbilt University Medical Center , Nashville, Tennessee.
Jeffrey M Davidson3 Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center , Nashville, Tennessee.
Scott A Guelcher1 Department of Biomedical Engineering, Vanderbilt University , Nashville, Tennessee.
Lillian B Nanney2 Department of Plastic Surgery, Vanderbilt University Medical Center , Nashville, Tennessee.
Craig L Duvall1 Department of Biomedical Engineering, Vanderbilt University , Nashville, Tennessee.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Substrate Mediated siRNA Delivery from Scaffolds to Promote Wound RepairR01EB019409 · NIBIB · VANDERBILT UNIVERSITY · PI Craig Lewis Duvall · 2014 to 2026
$4.0M
Integrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9M
NCI NIH HHS P30 CA068485NIBIB NIH HHS R01 EB019409NIDDK NIH HHS T32 DK101003NIDDK NIH HHS U24 DK059637
6 · The paper itself

Abstract

Impaired wound healing that mimics chronic human skin pathologies is difficult to achieve in current animal models, hindering testing and development of new therapeutic biomaterials that promote wound healing. In this article, we describe a refinement and simplification of the porcine ischemic wound model that increases the size and number of experimental sites per animal. By comparing three flap geometries, we adopted a superior configuration (15 × 10 cm) that enabled testing of twenty 1 cm

Indexed as

Materials TestingAnimalsBiocompatible MaterialsBlood VesselsDisease Models, AnimalIschemiaMacrophagesSkinSurgical FlapsSus scrofaTissue ScaffoldsWound HealingBiocompatible Materialsanimal modelbipedicle flapischemiapoly (thioketal)porcinereactive oxygen species

Identifiers

PMID28762881
PMCPMC5689114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.