Evidence map›Paper›PMID 28762878›Full record

Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018

Long-acting statin for aneurysmal subarachnoid hemorrhage: A randomized, double-blind, placebo-controlled trial.

Masato Naraoka, Naoya Matsuda, Norihito Shimamura, Kenichiro Asano, Kenichi Akasaka, Atsuhito Takemura, Seiko Hasegawa, Hiroki Ohkuma

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Role of microcirculatory impairment in delayed cerebral ischemia and outcome after aneurysmal subarachnoid hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Trial
  8. Article
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  10. Article
  11. Article
  12. Review
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  15. Article
  16. Review
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  18. Article
  19. Spontaneous subarachnoid haemorrhage.Lancet (London, England) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Masato Naraoka1 Department of Neurosurgery, Hirosaki University School of Medicine & Hospital, Hirosaki, Japan.
Naoya Matsuda1 Department of Neurosurgery, Hirosaki University School of Medicine & Hospital, Hirosaki, Japan.
Norihito Shimamura1 Department of Neurosurgery, Hirosaki University School of Medicine & Hospital, Hirosaki, Japan.
Kenichiro Asano1 Department of Neurosurgery, Hirosaki University School of Medicine & Hospital, Hirosaki, Japan.
Kenichi Akasaka2 Department of Neurosurgery, Towada City Hospital, Towada, Japan.
Atsuhito Takemura3 Department of Neurosurgery, Aomori City Hospital, Aomori, Japan.
Seiko Hasegawa4 Department of Neurosurgery, Kuroishi City Hospital, Kuroishi, Japan.
Hiroki Ohkuma1 Department of Neurosurgery, Hirosaki University School of Medicine & Hospital, Hirosaki, Japan.
Hirosaki University Hospital · JPAomori Rosai Hospital · JPKushiro City General Hospital · JPTowada City Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statins have pleiotropic effects that are considered beneficial in preventing cerebral vasospasm and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage (aSAH). Many studies using statins have been performed but failed to show remarkable effects. We hypothesized that a long-acting statin would be more effective, due to a longer half-life and stronger pleiotropic effects. Patients with aSAH were randomly assigned to a pitavastatin group (4 mg daily; n = 54) and a placebo group ( n = 54) after repair of a ruptured aneurysm. The primary efficacy end point was vasospasm-related delayed ischemic neurological deficits (DIND), and the secondary end points were cerebral vasospasm evaluated by digital subtraction angiography (DSA), vasospasm-related new cerebral infarctions, and outcome at three months. Severe cerebral vasospasms on DSA were statistically fewer in the pitavastatin group than in the placebo group (14.8% vs. 33.3%; odds ratio, 0.32; 95% confidence interval, 0.11-0.87, p = 0.042); however, the occurrence of DIND and new infarctions and outcome showed no statistically significant differences between the groups. The present study is the first to prove the definite, statin-induced amelioration of cerebral vasospasm on DSA. However, administration of any type of statin at the acute phase of aSAH is not recommended.

Indexed as

AdultAgedAneurysm, RupturedDelayed-Action PreparationsDouble-Blind MethodFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntracranial AneurysmMaleMiddle AgedQuinolinesSubarachnoid HemorrhageVasospasm, IntracranialDelayed-Action PreparationsHydroxymethylglutaryl-CoA Reductase InhibitorspitavastatinQuinolinesangiographyclinical trialsrandomized controlled trialsSubarachnoid hemorrhagevasospasm

Identifiers

PMID28762878
PMCPMC6434445
OpenAlexW2740165764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.