Evidence map›Paper›PMID 28762754›Full record

ArticleAntioxidants & redox signaling2018

Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Isoform Epsilon Signaling Mediates Glycolytic Metabolites for Vascular Repair.

Kyung In Baek, Rongsong Li, Nelson Jen, Howard Choi, Amir Kaboodrangi, Peipei Ping, David Liem, Tyler Beebe, Tzung K Hsiai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants & redox signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Cigarette Smoking-RegulatedEnvironment & health (Washington, D.C.) · 2026
    Article
  2. Review
  3. Endothelial Metabolic Reprogramming Links Diabetes to Atherosclerosis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  4. Review
  5. Microfluidic Device Type Improves Heart mRNA DeliveryLangmuir : the ACS journal of surfaces and colloids · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kyung In Baek1 Department of Bioengineering, School of Engineering and Applied Science, University of California , Los Angeles, Los Angeles, California.
Rongsong Li2 Division of Cardiology, Department of Medicine, University of California , Los Angeles, Los Angeles, California.
Nelson Jen1 Department of Bioengineering, School of Engineering and Applied Science, University of California , Los Angeles, Los Angeles, California.
Howard Choi2 Division of Cardiology, Department of Medicine, University of California , Los Angeles, Los Angeles, California.
Amir Kaboodrangi1 Department of Bioengineering, School of Engineering and Applied Science, University of California , Los Angeles, Los Angeles, California.
Peipei Ping2 Division of Cardiology, Department of Medicine, University of California , Los Angeles, Los Angeles, California.
David Liem2 Division of Cardiology, Department of Medicine, University of California , Los Angeles, Los Angeles, California.
Tyler Beebe1 Department of Bioengineering, School of Engineering and Applied Science, University of California , Los Angeles, Los Angeles, California.
Tzung K Hsiai1 Department of Bioengineering, School of Engineering and Applied Science, University of California , Los Angeles, Los Angeles, California.
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · US

Funding

Linking Spatial Variations Shear Stress-Oxidative StressR01HL083015 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K · 2006 to 2015
$3.9M
Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5M
Electronica Impedance to Access Metabolically Active PlaqueR01HL118650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K · 2014 to 2022
$3.3M
Micro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1M
NHLBI NIH HHS R01 HL083015NHLBI NIH HHS R01 HL111437NHLBI NIH HHS R01 HL118650NHLBI NIH HHS R01 HL129727
6 · The paper itself

Abstract

aimsHemodynamic shear stress participates in maintaining vascular redox status. Elucidating flow-mediated endothelial metabolites enables us to discover metabolic biomarkers and therapeutic targets. We posited that flow-responsive vascular endothelial growth factor receptor (VEGFR)-protein kinase C isoform epsilon (PKCɛ)-6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) signaling modulates glycolytic metabolites for vascular repair.

resultsBidirectional oscillatory flow (oscillatory shear stress [OSS]: 0.1 ± 3 dyne·cm

Indexed as

Regional Blood FlowSignal TransductionStress, MechanicalAnimalsCells, CulturedEndothelial CellsGlycolysisHumansMiceNeovascularization, PhysiologicPhosphofructokinase-2Protein Kinase C-epsilonReceptors, Vascular Endothelial Growth FactorRNA, MessengerZebrafishPFKFB3 protein, humanPhosphofructokinase-2Protein Kinase C-epsilonReceptors, Vascular Endothelial Growth FactorRNA, MessengerdihydroxyacetonemetabolitesPFKFB3PKCɛshear stressvascular repair

Identifiers

PMID28762754
PMCPMC5695747
OpenAlexW2741354943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.