Evidence map›Paper›PMID 28762653›Full record

ReviewWiley interdisciplinary reviews. RNA2017

Single cell transcriptomics of noncoding RNAs and their cell-specificity.

Katerina A B Gawronski, Junhyong Kim

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Wiley interdisciplinary reviews. RNA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. CCL5 mRNA-enriched small extracellular vesicles from renal tubular epithelial cells enhance macrophage inflammatory responses in diabetic nephropathy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  15. Oral mucositis: the hidden side of cancer therapy.Journal of experimental & clinical cancer research : CR · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Katerina A B GawronskiDepartment of Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Junhyong KimDepartment of Biology, Penn Program in Single Cell Biology, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Role of Single Cell mRNA Variation in Systems Associated Electrically Excitable CU01MH098953 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI EBERWINE, JAMES H, KIM, JUNHYONG · 2012 to 2016
$11.4M
VANADIUM INTERACTION STUDIES IN RELATION TO THE INHIBITION OF NA+-K+-ATPASES06GM008216 · NIGMS · UNIVERSITY OF PUERTO RICO AT HUMACAO · PI BARLETTA, GABRIEL LUIS · 1989 to 2010
$8.0M
NIGMS NIH HHS S06 GM008216NIMH NIH HHS U01 MH098953
6 · The paper itself

Abstract

Recent developments of single cell transcriptome profiling methods have led to the realization that many seemingly homogeneous cells have surprising levels of expression variability. The biological implications of the high degree of variability is unclear but one possibility is that many genes are restricted in expression to small lineages of cells, suggesting the existence of many more cell types than previously estimated. Noncoding RNA (ncRNA) are thought to be key parts of gene regulatory processes and their single cell expression patterns may help to dissect the biological function of single cell variability. Technology for measuring ncRNA in single cell is still in development and most of the current single cell datasets have reliable measurements for only long noncoding RNA (lncRNA). Most works report that lncRNAs show lineage-specific restricted expression patterns, which suggest that they might determine, at least in part, lineage fates and cell subtypes. However, evidence is still inconclusive as to whether lncRNAs and other ncRNAs are more lineage-specific than protein-coding genes. Nevertheless, measurement of ncRNAs in single cells will be important for studies of cell types and single cell function. WIREs RNA 2017, 8:e1433. doi: 10.1002/wrna.1433 For further resources related to this article, please visit the WIREs website.

Indexed as

AnimalsGene Expression ProfilingHumansOrgan SpecificityRNA, Long NoncodingRNA, Long Noncoding

Identifiers

PMID28762653
PMCPMC5675046

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.