ArticleNeurogastroenterology and motility2018
Perinatal high fat diet increases inhibition of dorsal motor nucleus of the vagus neurons regulating gastric functions.
Article in Neurogastroenterology and motility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Experience-dependent development of vagal circuitry in rodents and humans.Neuroscience and biobehavioral reviews · 2026Review
- Maternal obesity and the embryonic rewiring of feeding circuits: Beyond the hypothalamus.Molecular metabolism · 2026Review
- Vagal GABAergic signaling in autonomic control of cardiometabolic function.American journal of physiology. Cell physiology · 2026Review
- GABAiScience · 2025Article
- Early central cardiovagal dysfunction after high fat diet in a murine model.Scientific reports · 2023Article
- Brainstem astrocytes control homeostatic regulation of caloric intake.The Journal of physiology · 2023Article
- Sexual dimorphism in rats exposed to maternal high fat diet: alterations in medullary sympathetic network.Metabolic brain disease · 2021Article
- DMV extrasynaptic NMDA receptors regulate caloric intake in rats.JCI insight · 2021Article
- Glutamatergic plasticity within neurocircuits of the dorsal vagal complex and the regulation of gastric functions.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Protein Kinase C-Dependent Effects of Neurosteroids on Synaptic GABAFrontiers in physiology · 2021Article
- Interplay Between Systemic Metabolic Cues and Autonomic Output: Connecting Cardiometabolic Function and Parasympathetic Circuits.Frontiers in physiology · 2021Review
- GABAJournal of neurophysiology · 2019Article
- Sex differences in GABAergic neurotransmission to rat DMV neurons.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Perinatal high-fat diet alters development of GABAAmerican journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Role of astroglia in diet-induced central neuroplasticity.Journal of neurophysiology · 2019Review
- Central control of gastrointestinal motility.Current opinion in endocrinology, diabetes, and obesity · 2019Review
- High-Fat Diet During the Perinatal Period Induces Loss of Myenteric Nitrergic Neurons and Increases Enteric Glial Density, Prior to the Development of Obesity.Neuroscience · 2018Article
- Acute high-fat diet upregulates glutamatergic signaling in the dorsal motor nucleus of the vagus.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious studies suggest an increased inhibition of dorsal motor nucleus of the vagus (DMV) neurons following exposure to a perinatal high fat diet (PNHFD); the underlying neural mechanisms, however, remain unknown. This study assessed the effects of PNHFD on inhibitory synaptic inputs to DMV neurons and the vagally dependent control of gastric tone and motility.
methodsWhole-cell patch clamp recordings were made from DMV neurons in thin brainstem slices from Sprague-Dawley rats fed either a control diet or HFD (14 or 60% kcal from fat, respectively) from embryonic day 13 onwards; gastric tone and motility were recorded in in vivo anesthetized rats. KEY
resultsThe non-selective GABA CONCLUSIONS AND INFERENCES: These studies suggest that exposure to PNHFD increases the tonic inhibition of DMV neurons, possibly contributing to dysregulated vagal control of gastric functions.
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