Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

1. Complications of whole-exome sequencing for causal gene discovery in primary platelet secretion defects.Haematologica · 2019
   Trial
2. Utility of thromboelastography with platelet mapping for monitoring platelet transfusion in qualitative platelet disorders.Journal of thrombosis and haemostasis : JTH · 2024
   Article
3. High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis.Blood advances · 2023
   Article
4. Genetic Confirmation and Identification of Novel Variants for Glanzmann Thrombasthenia and Other Inherited Platelet Function Disorders: A Study by the Korean Pediatric Hematology Oncology Group (KPHOG).Genes · 2021
   Observational
5. When Actin is Not Actin' Like It Should: A New Category of Distinct Primary Immunodeficiency Disorders.Journal of innate immunity · 2021
   Review
6. Severe Bleeding Diathesis in Siblings with Platelet Dysfunction due to a Novel NonsenseTH open : companion journal to thrombosis and haemostasis · 2020
   Article
7. Subcellular localization of Rap1 GTPase activator CalDAG-GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides.Journal of thrombosis and haemostasis : JTH · 2020
   Article
8. RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology.International journal of molecular sciences · 2020
   Review
9. Impaired hemostatic activity of healthy transfused platelets in inherited and acquired platelet disorders: Mechanisms and implications.Science translational medicine · 2019
   Article
10. The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells.Scientific reports · 2019
    Article
11. Hereditary platelet function disorder fromHaematologica · 2019
    Article
12. RAP GTPases and platelet integrin signaling.Platelets · 2019
    Review
13. [The clinical characteristics and molecular pathogenesis of a variant Glanzmann's thrombasthenia-like pedigree].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2018
    Article
14. Introducing high-throughput sequencing into mainstream genetic diagnosis practice in inherited platelet disorders.Haematologica · 2018
    Article
15. Platelets at the Vascular Interface.Research and practice in thrombosis and haemostasis · 2018
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

15 authors at 4 institutions in 3 countries.

Funding

Abstract

Indexed as