ArticleEndocrine2017
Age-specific reference interval of serum TSH levels is high in adolescence in an iodine excess area: Korea national health and nutrition examination survey data.
Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- The Establishment of Reference Intervals for Thyroid Hormone Tests in the Korean Population: Using a Direct Selection Technique.Diagnostics (Basel, Switzerland) · 2025Article
- Predictive Modeling of Central Precocious Puberty Using IGF-1 and IGFBP-3 Standard Deviation Scores.Diagnostics (Basel, Switzerland) · 2025Article
- Thyrotropin reference interval in older adults.Endocrine connections · 2025Review
- Thyroid Hormone Reference Intervals among Healthy Individuals In Lanzhou, China.Endocrinology and metabolism (Seoul, Korea) · 2023Article
- A masquerade in a symptomatic patient with heart failure.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2023Article
- Impact of urinary iodine concentration on blood glucose levels and blood pressure: a nationwide population-based study.European journal of nutrition · 2022Article
- Update on Thyroid Hormone Levels and Thyroid Dysfunction in the Korean Population Based on Data from the Korea National Health and Nutrition Examination Survey VI (2013 to 2015).Endocrinology and metabolism (Seoul, Korea) · 2020Review
- Association between urinary sodium levels and iodine status in Korea.The Korean journal of internal medicine · 2020Article
- Non-immune-related hypothyroidism and its relationship with excess iodine.European journal of nutrition · 2019Article
- Evaluation of Thyroid Hormone Levels and Urinary Iodine Concentrations in Koreans Based on the Data from Korea National Health and Nutrition Examination Survey VI (2013 to 2015).Endocrinology and metabolism (Seoul, Korea) · 2018Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeSerum thyroid-stimulating hormone level was influenced by several factors, including age, gender, thyroid auto-antibodies, race, and intake of dietary iodine. We evaluated age-specific reference interval of serum thyroid-stimulating hormone levels in Korea, an iodine excess area.
methodsThis nationwide population-based cross-sectional study included representative civilian, non-institutional population (n = 6564) who underwent thyroid function tests from Korea National Health and Nutrition Examination Survey VI (2013-2015). The reference interval of serum thyroid-stimulating hormone levels was defined between the 2.5th and 97.5th percentiles in the reference population.
resultsThe geometric mean of serum thyroid-stimulating hormone levels in the reference population was 2.17 mIU/L with a reference interval of 0.62-6.84 mIU/L. In the reference population, the geometric mean of serum TSH levels in each age group of 10-18, 19-29, 30-39, 40-49, 50-59, 60-69, and equal or older than 70 years was 2.47, 2.20, 2.07, 2.04, 2.23, 2.12, and 2.27 mIU/L, with a reference interval of 0.74-7.35, 0.67-6.42, 0.63-6.04, 0.62-6.20, 0.56-7.37, 0.57-6.90, and 0.42-6.58 mIU/L, respectively. In the reference population, the urinary iodine concentrations were consistently high in all age groups (median 298.5 μg/L). Subjects aged 10-18 years had the highest urinary iodine concentrations.
conclusionsThere was no shift toward higher levels with age in the distribution of serum thyroid-stimulating hormone levels. The reference interval of serum thyroid-stimulating hormone levels was consistently high in all age group, especially from adolescence 10-18 years in a Korean population who had excessive intake of dietary iodine.
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