Evidence map›Paper›PMID 28762192›Full record

ReviewNeurology and therapy2017

A Comprehensive Review on Copemyl

Pietro Annovazzi, Antonio Bertolotto, Vincenzo Brescia Morra, Claudio Gasperini, Enrico Montanari, Pierluigi Navarra, Francesco Patti, Maria Pia Sormani, Angelo Ghezzi

Abstract readReview
In one paragraph

Review in Neurology and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pietro AnnovazziMultiple Sclerosis Study Center, ASST Valle Olona, Gallarate, VA, Italy. pietro.annovazzi@asst-valleolona.it.
Antonio BertolottoNeurology and Multiple Sclerosis Regional Reference Center (CRESM), AOU San Luigi, Orbassano, Italy.
Vincenzo Brescia MorraMultiple Sclerosis Clinical Care and Research Center, Departement of Neuroscience (NSRO), Federico II University, Naples, Italy.
Claudio GasperiniMultiple Sclerosis Center, S. Camillo-Forlanini Hospital Rome, Rome, Italy.
Enrico MontanariIntegrated Neurological Pole, Ausl-Aou Parma, Parma, Italy.
Pierluigi NavarraInstitute of Pharmacology, Catholic University Medical School, Largo F. Vito 1, 00168, Rome, Italy.
Francesco PattiDepartment of Medical and Surgical Sciences, and Advanced Technologies, GF Ingrassia, Multiple Sclerosis Center, University of Catania, Catania, Italy.
Maria Pia SormaniDepartment of Health Sciences, Section of Biostatistics, University of Genova, Genoa, Italy.
Angelo GhezziMultiple Sclerosis Study Center, ASST Valle Olona, Gallarate, VA, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Economic sustainability is of paramount importance in the rapidly evolving therapeutic scenario of multiple sclerosis (MS). Glatiramoids are a class of drugs whose forefather, glatiramer acetate, has been used as a disease modifying drug (DMD) in patients with MS for over 20 years. Its patent expired in 2015; new versions of such drug are nowadays available on the market, potentially contributing to lowering prices and enhancing a better allocation of economic resources. In this review, we analyze the recommendations underlying the approval of both generic drugs and biosimilars by regulatory authorities, and we provide methodological tools to contextualize the design of studies on these new classes of drugs. We examine in more detail the preclinical and clinical data of Copemyl

Indexed as

BioequivalenceCopemyl®Glatiramer acetateGlatiramoidMultiple sclerosisNon-biological complex drugs

Identifiers

PMID28762192
PMCPMC5700901

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.