ArticleInternational urogynecology journal2018
The influence of duloxetine on detrusor overactivity in rats with depression induced by 13-cis-retinoic acid.
Article in International urogynecology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 10 citations in OpenAlex.
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- Review
- Fluoxetine, a selective serotonin reuptake inhibitor used clinically, improves bladder function in a mouse model of moderate spinal cord injury.Neural regeneration research · 2021Article
- Psychiatric History and Overactive Bladder Symptom Severity in Ambulatory Urogynecological Patients.Journal of clinical medicine · 2021Article
- Small compounds mimicking the adhesion molecule L1 improve recovery in a zebrafish demyelination model.Scientific reports · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
introduction and hypothesisThe aim of this study was to assess the efficacy of duloxetine in an animal model of detrusor overactivity induced by depression.
methodsAfter 6 weeks of 13-cis-retinoic acid administration at a dose of 1 mg/kg/day, rats were given duloxetine at a dose of 1 mg/kg. This was followed by conscious cystometry, a forced swim test, and locomotor activity measurement. The levels of corticotropin-releasing factor (CRF) in the hypothalamus, amygdala and plasma were also determined.
resultsDuloxetine treatment led to a reduction in detrusor overactivity symptoms induced by the retinoid. Decreases were observed in cystometric parameters including the detrusor overactivity index, and the amplitude and frequency of nonvoiding contractions, while increases were seen in bladder compliance and the volume threshold to elicit nonvoiding contractions. No statistically significant differences were found in basal pressure, threshold pressure, micturition voiding pressure, postvoid residual , volume threshold, voiding efficiency, intercontraction interval, bladder contraction duration or relaxation time. Duloxetine also reduced the immobility time to that observed in control animals, while it did not affect locomotor activity. Its effects also included lowering of the CRF levels in the hypothalamus, amygdala and plasma, which increased following the prior administration of the retinoid. The plasma level of 13-cis-retinoic acid in rats corresponded to the levels found in humans.
conclusionsThis is the first study showing the efficacy of duloxetine in an animal model of detrusor overactivity induced by depression. Further studies in patients with detrusor overactivity and coexisting depression are warranted to confirm these experimental results.
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