Trial reportAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2018
Depression Symptoms in Haemodialysis Patients Predict All-Cause Mortality but Not Kidney Transplantation: A Cause-Specific Outcome Analysis.
Trial report in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Diabetic Foot Ulceration in Dialysis-Dependent End-Stage Kidney Disease: A Systematic Review of Epidemiology, Clinical Outcomes and Mortality Risk.Diabetes/metabolism research and reviews · 2026Pooled it
- Do psycho-behavioural interventions improve mental and physical health in chronic kidney disease? A systematic review of randomised controlled trials.Journal of nephrology · 2025Pooled it
- Interventions for fatigue in people with kidney failure requiring dialysis.The Cochrane database of systematic reviews · 2023Pooled it
- Psychosocial interventions for preventing and treating depression in dialysis patients.The Cochrane database of systematic reviews · 2019Pooled it
- Mental health and kidney disease.Nature reviews. Nephrology · 2026Review
- Interaction between anxiety, depression, and low resilience predicts poor prognosis in patients with chronic kidney disease.World journal of psychiatry · 2025Article
- Depression and anxiety in people with kidney disease: understanding symptom variability, patient experience and preferences for mental health support.Journal of nephrology · 2025Article
- Quality of life in older immigrant adults on hemodialysis.PloS one · 2025Article
- Independent and joint influence of depression and advanced lung cancer inflammation index on mortality among individuals with chronic kidney disease.Frontiers in nutrition · 2024Article
- Depression and health-related quality of life in adolescents and young adults with childhood-onset end-stage kidney disease: a multicenter study in Japan.Clinical and experimental nephrology · 2023Article
- Depression is associated with frailty and lower quality of life in haemodialysis recipients, but not with mortality or hospitalization.Clinical kidney journal · 2023Article
- Somatic Symptoms of Depression Lose Association with Mortality upon Adjustment for Frailty: Analysis from the Fitness Haemodialysis Cohort.International journal of nephrology · 2023Article
- Depression and death anxiety among patients undergoing hemodialysis during the COVID-19 pandemic in Palestine: a cross sectional study.Frontiers in psychiatry · 2023Article
- Nature-Based Interventions for Psychological Wellbeing in Long-Term Conditions: A Systematic Review.International journal of environmental research and public health · 2022Review
- Development of a complex arts-based intervention for patients with end-stage kidney disease whilst receiving haemodialysis.Pilot and feasibility studies · 2021Article
- Fatigue, anxiety, depression and sleep quality in patients undergoing haemodialysis.BMC nephrology · 2021Article
- Examining the relationship between nutrition, quality of life, and depression in hemodialysis patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Association of DRD4 exon III and 5-HTTLPR VNTR genetic polymorphisms with psychiatric symptoms in hemodialysis patients.PloS one · 2021Article
- Illness perceptions predict mortality in patients with predialysis chronic kidney disease: a prospective observational study.BMC nephrology · 2020Observational
- Self-reported antidepressant use in haemodialysis patients is associated with increased mortality independent of concurrent depression severity.Clinical kidney journal · 2020Article
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 1 country.
Funding
Abstract
Background: Depression is common in haemodialysis (HD) patients and associated with poor outcomes. Purpose: To evaluate whether depression symptoms predict survival and transplantation in a large sample of haemodialysis patients using cause-specific survival models. Methods: Survival data was collected between April 2013 and November 2015, as part of the screening phase of a multicentre randomised placebo-controlled trial of sertraline in HD patients. Depression was measured using the Beck Depression Inventory-II (BDI-II) and the Patient Health Questionnaire-9 (PHQ-9). Demographic and clinical data were collected via a self-report questionnaire and medical records. Competing risk survival analysis involved cause-specific and subdistribution hazard survival models. All models were adjusted for appropriate covariates including co-morbidity and C-reactive protein (CRP) in a subanalysis. Results: Of 707 cases available for analysis, there were 148 deaths. The mean survival time was 787.5 days. Cumulative survival at 12 months was 88.5%. During the study follow-up period, there were 92 transplants. The cumulative transplant event rate at 12 months was 7.8%. In separate adjusted models, depression symptoms predicted mortality (BDI-II HR = 1.03 95% CI 1.01, 1.04; PHQ-9 HR = 1.04 95% CI 1.01, 1.06). With respect to screening cut-off scores, a PHQ-9 ≥ 10 was associated with mortality (HR = 1.51 95% CI 1.01, 2.19) but not a BDI-II ≥ 16. Depression symptoms were not associated with time to transplantation in either cause-specific or subdistribution model. Conclusions: Consistent with past findings in HD patients, depression symptoms predicted survival but were not associated with kidney transplantation. Suitable treatments for depression need further evaluation, and their impact upon quality of life and clinical outcomes determined. Trial Registration Number: (ISRCTN06146268).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.