Evidence map›Paper›PMID 28762023›Full record

Trial reportObesity surgery2018

Efficacy of Goal-Directed Fluid Therapy via Pleth Variability Index During Laparoscopic Roux-en-Y Gastric Bypass Surgery in Morbidly Obese Patients.

İsmail Demirel, Esef Bolat, Aysun Yıldız Altun, Mustafa Özdemir, Azize Beştaş

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04664699 nacompletednot on this mapstarted 2019, after this paper: background citation

Comparison of Standard Monitoring and Plethysmographic Variability Index-Guided Fluid Therapy In Severe Traumatic Brain Injury Patients Scheduled for Emergency Craniotomies: A Randomised Control Trial

TypeinterventionalSponsorUniversiti Sains MalaysiaRan2019 to 2020Enrolled64ConditionsSevere Traumatic Brain InjuryArmsPlethymographic Variability Index, Standard Monitoring
NCT06188299 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effects Of Intraoperative Different Fluid Therapy Protocols On Postoperative Renal Functions

TypeinterventionalSponsorAnkara City Hospital BilkentRan2022 to 2023Enrolled60ConditionsIntraoperative Fluid ManagementArmsRestricted Fluid Administration
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  18. Goal-directed fluid therapy in the perioperative setting.Journal of anaesthesiology, clinical pharmacology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

İsmail DemirelMedicine Faculty, Anesthesiology and Reanimation Department, Firat University, 23119, Elazig, Turkey. ismaildemirel23@gmail.com.ORCID 0000-0002-9183-8225
Esef BolatMedicine Faculty, Anesthesiology and Reanimation Department, Firat University, 23119, Elazig, Turkey.
Aysun Yıldız AltunMedicine Faculty, Anesthesiology and Reanimation Department, Firat University, 23119, Elazig, Turkey.
Mustafa ÖzdemirMedicine Faculty, Anesthesiology and Reanimation Department, Firat University, 23119, Elazig, Turkey.
Azize BeştaşMedicine Faculty, Anesthesiology and Reanimation Department, Firat University, 23119, Elazig, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is no well-recognized guideline for intraoperative fluid management in bariatric surgery. Goal-directed fluid therapy (GDFT) is a new concept of perioperative fluid management which was shown to improve patients' prognoses. Dynamic indicators may better predict fluid response compared to static indicators. In this study, we aimed to assess effects of administering GDFT protocol via Pleth Variability Index (PVI) in morbidly obese patients undergoing laparoscopic Roux-en-Y gastric bypass (RYGB) surgery.

methodsThe study included 60 patients who underwent elective laparoscopic RYGB surgery. Subjects were randomized to two groups as being managed with either standard fluid regimen (control group) or PVI (PVI group) during intraoperative period. After induction of general anesthesia, control group received 500 ml crystalloid bolus followed by 4-8 ml/kg/h infusion. Fluid management of the control group was guided by central venous pressure and mean arterial pressure. PVI group received 500 ml crystalloid bolus followed by 2 ml/kg/h infusion. If PVI had been > 14%, 250 ml colloid was administered. Norepinephrine was given by infusion to keep mean arterial pressure > 65 mmHg, if needed. Perioperative lactate levels, hemodynamic parameters, and renal functions were recorded.

resultsIn PVI group, volume of crystalloid and total fluid infusion during intraoperative period was significantly lower than the control group (p < 0.05). The groups did not significantly differ in terms of lactate or creatinine levels before or after the surgery (p > 0.05).

conclusionsThere is no need to administer extra volume of fluid to obese patients undergoing laparoscopic bariatric surgery. Use of dynamic indicators like PVI helps to decrease intraoperative volume of infused fluids with no effects on either intraoperative or postoperative lactate levels in laparoscopic bariatric interventions.

Indexed as

Health Status IndicatorsPatient Care PlanningAdultAnesthesia, GeneralFemaleFluid TherapyGastric BypassHumansIntraoperative CareIntraoperative PeriodLaparoscopyMaleMiddle AgedObesity, MorbidTreatment OutcomeAnesthesiaBariatric surgeryMorbid obesityPleth Variability Index

Identifiers

PMID28762023

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.