ArticleEuropean archives of psychiatry and clinical neuroscience2018
Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia.
Article in European archives of psychiatry and clinical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Childhood premorbid adjustment as a marker for 20-year impairments in schizophrenia spectrum disorder: results from the OPUS study.European child & adolescent psychiatry · 2026Trial
- Developmental Pathways From Childhood Neurodevelopmental Traits to Early Adolescent Psychiatric Dimensions: The Role of Environmental and Lifestyle Factors.JAACAP open · 2026Article
- Anterior Cingulate Cortex Glutamate Levels and Sensory Integration Are Associated in Individuals With Social Anhedonia: A Comparison Between 3T and 7T MRS.PsyCh journal · 2025Article
- Neurological soft signs in borderline personality disorder and schizophrenia.Borderline personality disorder and emotion dysregulation · 2025Article
- Anhedonia Across and Beyond the Schizophrenia Spectrum.Schizophrenia bulletin · 2025Review
- Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes.Nature reviews. Neurology · 2024Review
- Schizophrenia polygenic risk score in psychosis proneness.European archives of psychiatry and clinical neuroscience · 2023Article
- Neurological Soft Signs in Schizophrenia, a Picture of the Knowledge in the Last Decade: A Scoping Review.Healthcare (Basel, Switzerland) · 2023Article
- A tablet-based quantitative assessment of manual dexterity for detection of early psychosis.Frontiers in psychiatry · 2023Article
- The positive dimension of schizotypy is associated with a reduced attenuation and precision of self-generated touch.Schizophrenia (Heidelberg, Germany) · 2022Article
- Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis.European archives of psychiatry and clinical neuroscience · 2021Article
- Neurological soft signs and cognition in the late course of chronic schizophrenia: a longitudinal study.European archives of psychiatry and clinical neuroscience · 2021Article
- Posture and gait in the early course of schizophrenia.PloS one · 2021Article
- Affected neural networks as basis of disturbed motor function in schizophrenia.European archives of psychiatry and clinical neuroscience · 2020Article
- Postural Sway Abnormalities in Schizotypal Personality Disorder.Schizophrenia bulletin · 2019Article
- Perspectives on Machine Learning for Classification of Schizotypy Using fMRI Data.Schizophrenia bulletin · 2018Article
- Motor clusters reveal differences in risk for psychosis, cognitive functioning, and thalamocortical connectivity: evidence for vulnerability subtypes.Clinical psychological science : a journal of the Association for Psychological Science · 2018Article
- Distinct Associations of Motor Domains in Relatives of Schizophrenia Patients-Different Pathways to Motor Abnormalities in Schizophrenia?Frontiers in psychiatry · 2018Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Neurological soft signs (NSS) are one of the biomarkers for schizophrenia spectrum disorders. However, a few studies have examined the prevalence of NSS across the schizophrenia spectrum. The present study adopted a quasi-longitudinal study design and examined the prevalence of NSS and their associations with clinical and behavioural manifestations in participants in different stages of the illness. The abridged version of the Cambridge Neurological Inventory was administered to 39 patients with the first-episode schizophrenia, 39 individuals with ultra-high risk (UHR) for psychosis, 39 individuals with schizotypy, and 39 healthy controls. Patients with the first-episode schizophrenia had a higher prevalence of NSS in motor coordination than healthy controls as well as individuals with UHR and schizotypy. Individuals with UHR exhibited a higher prevalence of sensory integration items than individuals with schizotypy and healthy controls. Discriminant analysis classified the membership of the individuals correctly across the spectrum with an accuracy of up to 60.9%. In particular, NSS could discriminate individuals with UHR from healthy controls at up to 85.9% accuracy. These findings suggest that NSS are robust biomarkers to detect and discriminate individuals in different stages of the schizophrenia spectrum from healthy controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.