Evidence map›Paper›PMID 28761934›Full record

ArticlemSystems

Metabolic Fingerprints from the Human Oral Microbiome Reveal a Vast Knowledge Gap of Secreted Small Peptidic Molecules.

Anna Edlund, Neha Garg, Hosein Mohimani, Alexey Gurevich, Xuesong He, Wenyuan Shi, Pieter C Dorrestein, Jeffrey S McLean

Open access · goldAbstract read
In one paragraph

Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Small molecule natural products in human nasal/oral microbiota.Journal of industrial microbiology & biotechnology · 2021
    Review
  8. The evolution and changing ecology of the African hominid oral microbiome.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Expanding the Vocabulary of Peptide Signals inFrontiers in cellular and infection microbiology · 2019
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. The Oral Microbiome Bank of China.International journal of oral science · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Anna EdlundGenomic Medicine Group, J. Craig Venter Institute, La Jolla, California, USA.
Neha GargCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
Hosein MohimaniDepartment of Computer Science and Engineering, University of California, San Diego, La Jolla, California, USA.
Alexey GurevichCenter for Algorithmic Biotechnology, Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
Xuesong HeSchool of Dentistry, University of California, Los Angeles, California, USA.
Wenyuan ShiSchool of Dentistry, University of California, Los Angeles, California, USA.
Pieter C DorresteinCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
Jeffrey S McLeanDepartment of Periodontics, University of Washington School of Dentistry, Seattle, Washington, USA.
University of California, San Diego · USUniversity of California, Los Angeles · USJ. Craig Venter Institute · USSt Petersburg University · RUUniversity of Washington · US

Funding

TrainingP41GM103484 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANDEIRA, NUNO · 2012 to 2018
$8.7M
Domestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6M
Making a quantum leap in plaque research with modern sciencesR01DE020102 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, XUESONG, MCLEAN, JEFFREY SCOTT · 2010 to 2020
$3.7M
Studying the Protective Effects of Normal Oral FloraR01DE026186 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, XUESONG, MCLEAN, JEFFREY SCOTT · 2016 to 2020
$2.1M
Moving Beyond Diversity by Revealing Biological Functions of Uncultured BacteriaR01GM095373 · NIGMS · J. CRAIG VENTER INSTITUTE, INC. · PI MCLEAN, JEFFREY SCOTT, YOOSEPH, SHIBU · 2011 to 2014
$1.7M
Investigating Oral Pathogen Virulence within Complex Oral Biofilm CommunitiesR00DE024543 · NIDCR · J. CRAIG VENTER INSTITUTE, INC. · PI EDLUND, ANNA ELISABET · 2016 to 2018
$732k
Investigating oral pathogen virulence within complex oral biofilm communitiesK99DE024543 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDLUND, ANNA ELISABET · 2014 to 2015
$188k
NIDCR NIH HHS K99 DE024543NIDCR NIH HHS R00 DE024543NIDCR NIH HHS R01 DE020102NIDCR NIH HHS R01 DE023810NIDCR NIH HHS R01 DE026186NIGMS NIH HHS P41 GM103484NIGMS NIH HHS R01 GM095373
6 · The paper itself

Abstract

Recent research indicates that the human microbiota play key roles in maintaining health by providing essential nutrients, providing immune education, and preventing pathogen expansion. Processes underlying the transition from a healthy human microbiome to a disease-associated microbiome are poorly understood, partially because of the potential influences from a wide diversity of bacterium-derived compounds that are illy defined. Here, we present the analysis of peptidic small molecules (SMs) secreted from bacteria and viewed from a temporal perspective. Through comparative analysis of mass spectral profiles from a collection of cultured oral isolates and an established

Indexed as

biofilmsLactobacillusoral microbiologypeptidic small moleculesStreptococcusVeillonella

Identifiers

PMID28761934
PMCPMC5516222
OpenAlexW2739475138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.