ArticleNeurology(R) neuroimmunology & neuroinflammation2017
MRI evaluation of thalamic volume differentiates MS from common mimics.
Article in Neurology(R) neuroimmunology & neuroinflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed.
- GOUHFI: A novel contrast- and resolution-agnostic segmentation tool for ultra-high-field MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms.Nature communications · 2022Article
- Oxidative Stress Markers in Cerebrospinal Fluid of Newly Diagnosed Multiple Sclerosis Patients and Their Link to Iron Deposition and Atrophy.Diagnostics (Basel, Switzerland) · 2022Article
- A local group differences test for subject-level multivariate density neuroimaging outcomes.Biostatistics (Oxford, England) · 2021Article
- Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis.JCI insight · 2020Article
- The Impact of Intracortical Lesions on Volumes of Subcortical Structures in Multiple Sclerosis.AJNR. American journal of neuroradiology · 2020Article
- Visualizing the Central Nervous System: Imaging Tools for Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders.Frontiers in neurology · 2020Review
- Altered Coupling of Psychological Relaxation and Regional Volume of Brain Reward Areas in Multiple Sclerosis.Frontiers in neurology · 2020Article
- Automatic Thalamus Segmentation on Unenhanced 3D T1 Weighted Images: Comparison of Publicly Available Segmentation Methods in a Pediatric Population.Neuroinformatics · 2019Article
- Quantitative 7T MRI does not detect occult brain damage in neuromyelitis optica.Neurology(R) neuroimmunology & neuroinflammation · 2019Article
- Uncovering convolutional neural network decisions for diagnosing multiple sclerosis on conventional MRI using layer-wise relevance propagation.NeuroImage. Clinical · 2019Article
- Cognitive Impairment in Neuromyelitis Optica Spectrum Disorders: A Review of Clinical and Neuroradiological Features.Frontiers in neurology · 2019Review
- The Emerging Role of Neutrophil Granulocytes in Multiple Sclerosis.Journal of clinical medicine · 2018Review
- A Peptide Targeting Inflammatory CNS Lesions in the EAE Rat Model of Multiple Sclerosis.Inflammation · 2018Article
- Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy.The EPMA journal · 2018Review
- MRI Markers and Functional Performance in Patients With CIS and MS: A Cross-Sectional Study.Frontiers in neurology · 2018Article
- Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI.NeuroImage. Clinical · 2018Review
- Tremor in multiple sclerosis is associated with cerebello-thalamic pathology.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Vitamin D in the prevention, prediction and treatment of neurodegenerative and neuroinflammatory diseases.The EPMA journal · 2017Review
- The tension between early diagnosis and misdiagnosis of multiple sclerosis.Nature reviews. Neurology · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo determine whether MRI evaluation of thalamic volume differentiates MS from other disorders that cause MRI white matter abnormalities.
methodsThere were 40 study participants: 10 participants with MS without additional comorbidities for white matter abnormalities (MS - c); 10 participants with MS with additional comorbidities for white matter abnormalities (MS + c); 10 participants with migraine, MRI white matter abnormalities, and no additional comorbidities for white matter abnormalities (Mig - c); and 10 participants previously incorrectly diagnosed with MS (Misdx). T1-magnetization-prepared rapid gradient-echo and T2-weighted three-dimensional fluid attenuation inversion recovery sequences were acquired on a Phillips Achieva d-Stream 3T MRI, and scans were randomly ordered and de-identified for a blinded reviewer who performed MRI segmentation using LesionTOADS.
resultsMean normalized thalamic volume differed among the 4 cohorts (analysis of variance,
conclusionsMRI volumetric evaluation of the thalamus, but not other deep gray-matter structures, differentiated MS from other diseases that cause white matter abnormalities and are often mistaken for MS. Evaluation for thalamic atrophy may improve accuracy for diagnosis of MS as an adjunct to additional radiologic criteria. Thalamic volumetric assessment by MRI in larger cohorts of patients undergoing evaluation for MS is needed, along with the development of automated and easily applied volumetric assessment tools for future clinical application. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that MRI evaluation of thalamic volume differentiates MS from other diseases that cause white matter abnormalities.
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Registered trials
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