ArticleNeuroImage. Clinical2017
Cerebellar degeneration affects cortico-cortical connectivity in motor learning networks.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Effects of Anodal Cerebellar Transcranial Direct Current Stimulation on Movements in Patients with Cerebellar Ataxias: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Article
- First Application of a Novel Brain Template: Motor Training Improves Cortico-cerebellar Connectivity in Cerebellar Ataxia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- That's (relevant for) me: task-set-dependent brain responses to delayed visual movement feedback.Social cognitive and affective neuroscience · 2025Article
- A Review of theDiseases (Basel, Switzerland) · 2024Review
- Compressed cerebellar functional connectome hierarchy in spinocerebellar ataxia type 3.Human brain mapping · 2024Article
- Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults.iScience · 2023Article
- Visuomotor Adaptation Deficits in Patients with Essential Tremor.Cerebellum (London, England) · 2023Article
- Motor training-related brain reorganization in patients with cerebellar degeneration.Human brain mapping · 2022Article
- Role of Cortico-ponto-cerebellar Tract from Supplementary Motor Area in Ataxic Hemiparesis of Supratentorial Stroke Patients.Brain & NeuroRehabilitation · 2021Article
- PONT: A Protocol for Online Neuropsychological Testing.Journal of cognitive neuroscience · 2021Article
- The Cerebellum and Implicit Sequencing: Evidence from Cerebellar Ataxia.Cerebellum (London, England) · 2021Article
- Motor Sequence Learning Deficits in Idiopathic Parkinson's Disease Are Associated With Increased Substantia Nigra Activity.Frontiers in aging neuroscience · 2021Article
- New Horizons in Early Dementia Diagnosis: Can Cerebellar Stimulation Untangle the Knot?Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum plays an important role in motor learning as part of a cortico-striato-cerebellar network. Patients with cerebellar degeneration typically show impairments in different aspects of motor learning, including implicit motor sequence learning. How cerebellar dysfunction affects interactions in this cortico-striato-cerebellar network is poorly understood. The present study investigated the effect of cerebellar degeneration on activity in causal interactions between cortical and subcortical regions involved in motor learning. We found that cerebellar patients showed learning-related increase in activity in two regions known to be involved in learning and memory, namely parahippocampal cortex and cerebellar Crus I. The cerebellar activity increase was observed in non-learners of the patient group whereas learners showed an activity decrease. Dynamic causal modeling analysis revealed that modulation of M1 to cerebellum and putamen to cerebellum connections were significantly more negative for sequence compared to random blocks in controls, replicating our previous results, and did not differ in patients. In addition, a separate analysis revealed a similar effect in connections from SMA and PMC to M1 bilaterally. Again, neural network changes were associated with learning performance in patients. Specifically, learners showed a negative modulation from right SMA to right M1 that was similar to controls, whereas this effect was close to zero in non-learners. These results highlight the role of cerebellum in motor learning and demonstrate the functional role cerebellum plays as part of the cortico-striato-cerebellar network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.