Evidence map›Paper›PMID 28761722›Full record

ArticleCell discovery2017

A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population.

Feng Wang, Dong Liu, Ran-Ran Zhang, Li-Wei Yu, Jian-Yuan Zhao, Xue-Yan Yang, Song-Shan Jiang, Duan Ma, Bin Qiao, Feng Zhang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell discovery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Role of non-coding variants in cardiovascular disease.Journal of cellular and molecular medicine · 2023
    Review
  9. The role of noncoding genetic variants in cardiomyopathy.Frontiers in cardiovascular medicine · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Dysregulated micro-RNAs and long noncoding RNAs in cardiac development and pediatric heart failure.American journal of physiology. Heart and circulatory physiology · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Feng WangChildren's Hospital, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction & Development, Fudan University, Shanghai, China.
Dong LiuCo-innovation Center of Neuroregeneration, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, Nantong, China.ORCID 0000-0002-2764-6544
Ran-Ran ZhangChildren's Hospital, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction & Development, Fudan University, Shanghai, China.
Li-Wei YuChildren's Hospital, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction & Development, Fudan University, Shanghai, China.
Jian-Yuan ZhaoThe State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Xue-Yan YangThe State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Song-Shan JiangThe State Key laboratory for Biocontrol and MOE Key Laboratory of Gene Engineering, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Duan MaKey Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Institute of Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Bin QiaoInstitute of Cardiovascular Disease, General Hospital of Jinan Military Region, Jinan, China.
Feng ZhangThe Obstetrics & Gynecology Hospital, Key Laboratory of Reproduction Regulation of NPFPC, Institute of Reproduction & Development, Fudan University, Shanghai, China.
Li JinThe State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Yong-Hao GuiChildren's Hospital, State Key Laboratory of Genetic Engineering at School of Life Sciences, Institute of Reproduction & Development, Fudan University, Shanghai, China.
Hong-Yan WangThe Obstetrics & Gynecology Hospital, Key Laboratory of Reproduction Regulation of NPFPC, Institute of Reproduction & Development, Fudan University, Shanghai, China.
Children's Hospital of Fudan University · CNFudan University · CNObstetrics and Gynecology Hospital of Fudan University · CNJinan Military General Hospital · CNNantong University · CNShanghai Medical College of Fudan University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TBX5 is a vital transcription factor involved in cardiac development in a dosage-dependent manner. But little is known about the potential association of

Indexed as

3′UTRcongenital heart diseasemicroRNAsTBX5variant

Identifiers

PMID28761722
PMCPMC5527299
OpenAlexW2737530623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.