ArticleAnnals of medicine and surgery (2012)2017
Mean platelet volume and serum uric acid in neonatal sepsis: A case-control study.
Article in Annals of medicine and surgery (2012), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Diagnostic value of mean platelet volume for neonatal sepsis: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Constructing a machine learning model for systemic infection after kidney stone surgery based on CT values.Scientific reports · 2025Article
- Evaluation of Haematological Parameters and Uric Acid in the Diagnosis of Late Onset Neonatal Sepsis.Cureus · 2023Article
- Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies.Children (Basel, Switzerland) · 2022Review
- Platelet parameters as a diagnostic marker in early diagnosis of neonatal sepsis- Seeking newer answers for older problems.Journal of family medicine and primary care · 2022Article
- Mean platelet volume and red blood cell distribution width is associated with prognosis in premature neonates with sepsis.Open medicine (Warsaw, Poland) · 2021Article
- Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis.PloS one · 2020Observational
- Association of anti-hyperuricemia treatment and prevalent cardiovascular disease in hypertensive patients.Archives of medical science : AMS · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMean platelet volume (MPV) is a measure of platelet volume. It reveals the presence of inflammatory burden and disease activity in many diseases. Serum uric acid (SUA) is one of the most important antioxidants in human biological fluids and is responsible for neutralizing > 50% of the free radicals in the human blood. For this reason, it was thought that the antioxidant effects of SUA could increase the life expectancy and/or reduce the incidence of malignancy.
objectivesTo determine the role of mean platelet volume (MPV) and serum uric acid (SUA) level in the diagnosis of neonatal sepsis (NS).
methodsThis case-control study was done on 80 newborns divided into 3 groups: group A (n = 22): clinical NS, group B (n = 18): Proven NS and Group C (n = 40): apparently healthy control. All patients in the study were subjected to adequate assessment of history, full clinical examination, complete blood count including MPV, C - reactive protein (CRP), blood culture in CRP positive cases, and SUA level at the time of diagnosis of sepsis.
resultsSeptic neonates showed statistically higher values of MPV and statistically lower levels of SUA than the control group. The diagnostic cut-off values of MPV and SUA for NS were 10.2 fL, and 3.70 mg/dL, respectively.
conclusionsMPV could be assessed in the early diagnosis of neonatal sepsis while SUA level has lower sensitivity in neonatal sepsis.
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