ArticleNeural regeneration research2017
Critical signaling pathways during Wallerian degeneration of peripheral nerve.
Article in Neural regeneration research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride.Neurotoxicity research · 2025Article
- Neuritin accelerates Schwann cell dedifferentiation via PI3K/Akt/mTOR signalling pathway during Wallerian degeneration.Journal of cellular and molecular medicine · 2024Article
- Next-generation RNA sequencing elucidates transcriptomic signatures of pathophysiologic nerve regeneration.Scientific reports · 2023Article
- Effects of Different-Syllable Aggressive Calls on Food Intake and Gene Expression inAnimals : an open access journal from MDPI · 2023Article
- Article
- SIRT6 Negatively Regulates Schwann Cells Dedifferentiation via Targeting c-Jun During Wallerian Degeneration After Peripheral Nerve Injury.Molecular neurobiology · 2022Article
- The interaction of stem cells and vascularity in peripheral nerve regeneration.Neural regeneration research · 2021Article
- Schwann cell reprogramming and lung cancer progression: a meta-analysis of transcriptome data.Oncotarget · 2019Article
- Differential gene and protein expression between rat tibial nerve and common peroneal nerve during Wallerian degeneration.Neural regeneration research · 2019Article
- Systemic functional enrichment and ceRNA network identification following peripheral nerve injury.Molecular brain · 2018Article
- Transcriptome analysis of adherens junction pathway-related genes after peripheral nerve injury.Neural regeneration research · 2018Article
- Pathophysiological Changes of Physical Barriers of Peripheral Nerves After Injury.Frontiers in neuroscience · 2018Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wallerian degeneration is a critical biological process that occurs in distal nerve stumps after nerve injury. To systematically investigate molecular changes underlying Wallerian degeneration, we used a rat sciatic nerve transection model to examine microarray analysis outcomes and investigate significantly involved Kyoto Enrichment of Genes and Genomes (KEGG) pathways in injured distal nerve stumps at 0, 0.5, 1, 6, 12, and 24 hours, 4 days, 1, 2, 3, and 4 weeks after peripheral nerve injury. Bioinformatic analysis showed that only one KEGG pathway (cytokine-cytokine receptor interaction) was significantly enriched at an early time point (1 hour post-sciatic nerve transection). At later time points, the number of enriched KEGG pathways initially increased and then decreased. Three KEGG pathways were studied in further detail: cytokine-cytokine receptor interaction, neuroactive ligand-receptor interaction, and axon guidance. Moreover, temporal expression patterns of representative differentially expressed genes in these KEGG pathways were validated by real time-polymerase chain reaction. Taken together, the above three signaling pathways are important after sciatic nerve injury, and may increase our understanding of the molecular mechanisms underlying Wallerian degeneration.
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