Evidence map›Paper›PMID 28761424›Full record

ArticleNeural regeneration research2017

Neuroprotective effects of ischemic preconditioning on hippocampal CA1 pyramidal neurons through maintaining calbindin D28k immunoreactivity following subsequent transient cerebral ischemia.

In Hye Kim, Yong Hwan Jeon, Tae-Kyeong Lee, Jeong Hwi Cho, Jae-Chul Lee, Joon Ha Park, Ji Hyeon Ahn, Bich-Na Shin, Yang Hee Kim, Seongkweon Hong and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

In Hye KimDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Yong Hwan JeonDepartment of Radiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Tae-Kyeong LeeDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Jeong Hwi ChoDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Jae-Chul LeeDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Joon Ha ParkDepartment of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, South Korea.
Ji Hyeon AhnDepartment of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, South Korea.
Bich-Na ShinDepartment of Physiology, College of Medicine, Hallym University, Chuncheon, South Korea.
Yang Hee KimDepartment of Surgery, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Seongkweon HongDepartment of Surgery, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Bing Chun YanInstitute of Integrative Traditional & Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China.
Moo-Ho WonDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.ORCID 0000-0002-7178-6501
Yun Lyul LeeDepartment of Physiology, College of Medicine, Hallym University, Chuncheon, South Korea.ORCID 0000-0003-0504-5825
Kangwon National University · KRHallym University · KRYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult. In this study, we investigated the neuroprotective effects of ischemic preconditioning (2-minute transient cerebral ischemia) on calbindin D28k immunoreactivity in the gerbil hippocampal CA1 area following a subsequent fatal transient ischemic insult (5-minute transient cerebral ischemia). A large number of pyramidal neurons in the hippocampal CA1 area died 4 days after 5-minute transient cerebral ischemia. Ischemic preconditioning reduced the death of pyramidal neurons in the hippocampal CA1 area. Calbindin D28k immunoreactivity was greatly attenuated at 2 days after 5-minute transient cerebral ischemia and it was hardly detected at 5 days post-ischemia. Ischemic preconditioning maintained calbindin D28k immunoreactivity after transient cerebral ischemia. These findings suggest that ischemic preconditioning can attenuate transient cerebral ischemia-caused damage to the pyramidal neurons in the hippocampal CA1 area through maintaining calbindin D28k immunoreactivity.

Indexed as

calcium binding proteinhippocampusischemic tolerancenerve regenerationneural regenerationneuroprotectionpyramidal neuronstransient cerebral ischemia

Identifiers

PMID28761424
PMCPMC5514866
OpenAlexW2642010849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.