ReviewClinical and experimental gastroenterology2017
Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states.
Review in Clinical and experimental gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Amyloidosis for the Gastroenterologist: A Comprehensive Systematic Review of Diagnosis and Management of Gastrointestinal Manifestations.Journal of gastroenterology and hepatology · 2025Pooled it
- ANCA-associated vasculitis with protein-losing enteropathy is characterized by hypocomplementemia.Rheumatology international · 2022Pooled it
- Diagnostic value of delayed-phase 99mTc-HSA scintigraphy and treatment outcomes in connective tissue disease-associated protein-losing enteropathy.Clinical rheumatology · 2026Article
- Article
- Clinical characteristics and risk factors of protein-losing enteropathy: a retrospective study.Frontiers in immunology · 2026Article
- Successful Surgical Resection for Protein-Losing Enteropathy Caused by Ischemic Ileitis.Surgical case reports · 2026Article
- Serum biomarkers for predicting Crohn's disease activity: The role of bilirubin, uric acid, and the C-reactive protein/albumin ratio.PloS one · 2026Article
- Association between the C-reactive protein to albumin ratio and unplanned readmission in ulcerative colitis: insights from a cohort study.Frontiers in medicine · 2026Article
- A Normalized Spot-Sample Estimation of α-1 Antitrypsin Clearance: The Search for a Simpler Test in Protein Losing Enteropathy.World journal of nuclear medicine · 2025Article
- Cow's milk protein allergy with protein-losing enteropathy under the scope.JPGN reports · 2025Article
- A case of zolbetuximab-induced protein-losing gastroenteropathy in a patient with advanced gastric cancer.International cancer conference journal · 2025Article
- Intestinal Vicarious Contrast Medium Excretion on Delayed Computed Tomography in Dogs with Protein-Losing Enteropathy.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2025Article
- How cardiac output is controlled in a Fontan circulation: an update.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Elderly Onset Primary Intestinal Lymphangiectasia-A Rare Case.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Protein-Losing Enteropathy Caused by Ascending Colon Cancer without Polyposis: A Rare Case Diagnosed by Scintigraphy.Surgical case reports · 2025Article
- Secondary antibody deficiencies: what's around the corner?Frontiers in immunology · 2025Review
- Protein losing enteropathy due to congenital disorder of glycosylation: A case report.SAGE open medical case reports · 2025Article
- Life-Threatening Esophageal Variceal Hemorrhage in a 7-Year-Old Boy with Massive Portal Vein Enlargement Due to Congenital Arterioportal Fistula.The American journal of case reports · 2024Article
- The incidence and risk factors of gastrointestinal dysfunction during enteral nutrition in mechanically ventilated critically ill patients.Nursing open · 2024Observational
- Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein losing enteropathy (PLE) has been associated with more than 60 different conditions, including nearly all gastrointestinal diseases (Crohn's disease, celiac, Whipple's, intestinal infections, and so on) and a large number of non-gut conditions (cardiac and liver disease, lupus, sarcoidosis, and so on). This review presents the first attempt to quantitatively understand the magnitude of the PLE in relation to the associated pathology for three different disease categories: 1) increased lymphatic pressure (e.g., lymphangiectasis); 2) diseases with mucosal erosions (e.g., Crohn's disease); and 3) diseases without mucosal erosions (e.g., celiac disease). The PLE with lymphangiectasis results from rupture of the mucosal lymphatics, with retrograde drainage of systemic lymph into the intestinal lumen with the resultant loss of CD4 T cells, which is diagnostic. Mucosal erosion PLE results from macroscopic breakdown of the mucosal barrier, with the epithelial capillaries becoming the rate-limiting factor in albumin loss. The equation derived to describe the relationship between the reduction in serum albumin (C
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.