ArticleIranian journal of medical sciences2017
Pain Relief with Wet Cupping Therapy in Rats is Mediated by Heat Shock Protein 70 and ß-Endorphin.
Article in Iranian journal of medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Effects of fire dragon cupping therapy for patients with post-stroke shoulder-hand syndrome: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Trends and hotspots in cupping therapy research for pain: a bibliometric study.Frontiers in medicine · 2025Pooled it
- Efficacy of cupping therapy on pain outcomes: an evidence-mapping study.Frontiers in neurology · 2023Pooled it
- Cellular and Molecular Targets for Non-Invasive, Non-Pharmacological Therapeutic/Rehabilitative Interventions in Acute Ischemic Stroke.International journal of molecular sciences · 2022Pooled it
- The sliding cupping therapy as an alternative strategy for treating plaque psoriasis: A randomized controlled trial.Medicine · 2026Trial
- Efficacy and safety of bloodletting puncture and cupping in postherpetic neuralgia: A systematic review and meta‑analysis.Biomedical reports · 2024Article
- Cupping Therapy as an Adjunctive Therapy for Side Effects of Colorectal Cancer Treatment: A Prospective Observational Study.Journal of chiropractic medicine · 2022Article
- Positive short term effects of an integrative korean medicine treatment package for low back pain caused by motor vehicle accidents: A retrospective chart review of real - world practice data.Frontiers in pharmacology · 2022Article
- Cupping (Hijama) in Rheumatic Diseases: The Evidence.Mediterranean journal of rheumatology · 2021Review
- Effects of moving cupping therapy for plaque psoriasis: study protocol for a randomized multicenter clinical trial.Trials · 2020Article
- The Evidence for Common Nonsurgical Modalities in Sports Medicine, Part 2: Cupping and Blood Flow Restriction.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2020Review
- Proteomic effects of wet cupping (Al-hijamah).Saudi medical journal · 2018Review
- Effects of wet cupping in a rat model of primary dysmenorrhea.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWet cupping therapy is a complementary therapy in pain management. The mechanism of this therapy, however, needs further elucidation. Cells injured by wet cupping therapy seem to stimulate the expression of heat shock protein 70 (HSP70). Its benefit in pain reduction could be mediated by the expression of ß-endorphin. This study aimed at determining the correlation between HSP70 and ß-endorphin after wet cupping therapy.
methodsSixteen male Wistar rats were divided into control (CG; n=8) and treatment (TG; n=8) groups. The rats in both groups were injected with complete Freund's adjuvant (CFA) at the footpad. In the TG, wet cupping therapy was done at the left and right paralumbar regions 48 hours after the CFA injection. Twenty-four hours after therapy, the hot plate test was done to assess pain threshold. Thereafter, immunohistochemistry from the skin subjected to wet cupping therapy was conducted for HSP70 and ß-endorphin.
resultsThe expression of HSP70 was significantly higher in the keratinocytes of the TG (20.25±3.53; P<0.001) than in the keratinocytes of the CG (10.50±2.44; P<0.001). The expression of ß-endorphin was significantly higher in the keratinocytes of the TG (22.37±3.52; P<0.001) than in the keratinocytes of the CG (5.12±1.72; P<0.001). The results also revealed a high correlation between HSP70 and ß-endorphin (β=0.864; P<0.001). Pain threshold after wet cupping therapy was significantly higher in the TG (22.81±6.34 s; P=0.003) than in the CG (11.78±3.56 s).
conclusionsThe benefit of wet cupping therapy in terms of pain reduction in rats could be mediated by the expression of HSP70 and ß-endorphin.
Indexed as
Identifiers
28761205PMC5523046W2580341369What OpenQuestion holds
Registered trials
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