ArticleScientific reports2017
Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Integration of AI-driven ultrasound and molecular testing to improve diagnosis of indeterminate thyroid nodules.Frontiers in endocrinology · 2026Pooled it
- Comparison of diagnostic performance of two ultrasound risk stratification systems for thyroid nodules: a systematic review and meta-analysis.La Radiologia medica · 2023Pooled it
- Diagnostic performance of ultrasound risk stratification systems on thyroid nodules cytologically classified as indeterminate: a systematic review and meta-analysis.Ultrasonography (Seoul, Korea) · 2023Pooled it
- US-Elastography With Different Techniques for Thyroid Nodule Characterization: Systematic Review and Meta-analysis.Frontiers in oncology · 2022Pooled it
- Accuracy of Ultrasound Diagnosis of Benign and Malignant Thyroid Nodules: A Systematic Review and Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Multimodal risk assessment of malignancy in thyroidology for nodules with indeterminate cytology.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Review
- Clinical utility of histogram analysis of grayscale sonograms in assessing sonographic suspicious malignant thyroid nodules.Translational cancer research · 2022Article
- Use of Diagnostic Criteria from ACR and EU-TIRADS Systems to Improve the Performance of Cytology in Thyroid Nodule Triage.Cancers · 2021Article
- Thyroid Nodule Characterization: How to Assess the Malignancy Risk. Update of the Literature.Diagnostics (Basel, Switzerland) · 2021Review
- Implications of US radiomics signature for predicting malignancy in thyroid nodules with indeterminate cytology.European radiology · 2021Article
- The combination of ATA classification and FNA results can improve the diagnostic efficiency of malignant thyroid nodules.Endocrine connections · 2020Article
- ACR TI-RADS and ATA US scores are helpful for the management of thyroid nodules with indeterminate cytology.BMC endocrine disorders · 2019Observational
- Diagnostic value of multimodal ultrasound imaging in differentiating benign and malignant TI-RADS category 4 nodules.International journal of clinical oncology · 2019Article
- Echogenic foci in thyroid nodules: diagnostic performance with combination of TIRADS and echogenic foci.BMC medical imaging · 2019Article
- Role of Strain Elastography and Shear-Wave Elastography in a Multiparametric Clinical Approach to Indeterminate Cytology Thyroid Nodules.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Approaching Indeterminate Thyroid Nodules in the Absence of Molecular Markers: "The BETH-TR Score".Indian journal of endocrinology and metabolismArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the diagnostic performance of combination of ultrasound (US) thyroid imaging reporting and data system (TI-RADS) and a new US scoring system for diagnosing thyroid nodules (TNs) with indeterminate results (Bethesda categories III, IV and V) on fine-needle aspiration (FNA) cytology. 453 patients with 453 cytologically indeterminate TNs were included in this study. Multivariate analyses were performed to construct the scoring system. The diagnostic performances of TI-RADS and the combined method were evaluated and compared. Multivariate analyses revealed that marked hypoechogenicity, taller than wide shape and absence of halo sign were independent predictors for malignancy in cytologically indeterminate TNs. Scoring system was thereafter defined as follows: risk score (RS) = 3.2 x (if marked hypoechogenicity) + 2.8 x (if taller than wide shape) + 1.3 x (if absence of halo sign). Compared with TI-RADS alone, the areas under the receiver operating characteristic curves (AUC), specificity, accuracy and positive predictive value (PPV) of the combined method increased significantly with 0.731 versus 0.569, 48.5% versus 14.1%, 76.2% versus 62.3%, and 70.9% versus 59.9%, respectively (all P < 0.05). The combination of TI-RADS and new US scoring system showed superior diagnostic performances in predicting malignant TNs with indeterminate FNA cytology results in comparison with TI-RADS alone.
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