ArticleScientific reports2017
Ethylene, an early marker of systemic inflammation in humans.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Uncovering the connection: ethylene exposure and endogenous ethylene oxide levels in humans.Journal of exposure science & environmental epidemiology · 2026Review
- Allies or Enemies? The Power of Plant Hormones in Animals: Insights into Their Regulatory Roles.Molecules (Basel, Switzerland) · 2025Review
- Exploring the use of exhaled breath profiling for non-invasive monitoring of cognitive functioning in children: a pilot study.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Characterization of Background Exposures to Ethylene Oxide in the United States: A Reality Check on Theoretical Health Risks for Potentially Exposed Populations near Industrial Sources.International journal of environmental research and public health · 2025Article
- An Amplificative Detection Approach for Autocatalytic Sensing of Ethylene.Journal of the American Chemical Society · 2025Article
- The Potential Diagnostic Utility of SMAD4 and ACCS in the Context of Inflammation in Type 2 Diabetes Mellitus Patients.Biomedicines · 2024Article
- Oxygen is an essential gasotransmitter directly sensed via protein gasoreceptors.Animal models and experimental medicine · 2024Article
- Red-shifted activity-based sensors for ethyleneRSC chemical biology · 2023Article
- Detection of Ethylene with Defined Metal Complexes: Strategies and Recent Advances.Analysis & sensing · 2023Article
- The bioactive potential of phytohormones: A review.Biotechnology reports (Amsterdam, Netherlands) · 2022Review
- Physiological and metabolic effects of healthy female aging on exhaled breath biomarkers.iScience · 2022Article
- Bioactivity of Inhaled Methane and Interactions With Other Biological Gases.Frontiers in cell and developmental biology · 2021Review
- COBiosensors · 2020Article
- Digital Resilience Biomarkers for Personalized Health Maintenance and Disease Prevention.Frontiers in digital health · 2020Review
- Analysis of Human Breath by Millimeter-Wave/Terahertz Spectroscopy.Sensors (Basel, Switzerland) · 2019Article
- Hydrogen Gas in Cancer Treatment.Frontiers in oncology · 2019Review
- Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second.Frontiers in immunology · 2019Article
- Laser spectroscopy for breath analysis: towards clinical implementation.Applied physics. B, Lasers and optics · 2018Article
- Diagnosis of acute respiratory distress syndrome by exhaled breath analysis.Annals of translational medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.