ArticleScientific reports2017
Single vector non-leaky gene expression system for Drosophila melanogaster.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Light-inducible FLPase reconstitution enables temporal control of gene expression in Drosophila melanogaster.Cell reports methods · 2026Article
- Characterization of Heat Shock Protein Expression and Its Application to Temporal Gene Expression in the Nematode Pristionchus pacificus.Development, growth & differentiation · 2026Article
- A linamarase transgene controlled by heatshock creates a pro-toxin activation system inmicroPublication biology · 2025Article
- TransgenicCurrent issues in molecular biology · 2024Article
- Development of membrane protein-based vaccine against lumpy skin disease virus (LSDV) using immunoinformatic tools.Veterinary medicine and science · 2024Article
- Kalium channelrhodopsins effectively inhibit neurons.Nature communications · 2024Article
- Polycomb response elements reduce leaky expression of Cas9 under temperature-inducible Hsp70Bb promoter in Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Uric acid metabolism modulates diet-dependent responses to intraspecific competition iniScience · 2022Article
- Article
- In silico design and analyses of a multi-epitope vaccine against Crimean-Congo hemorrhagic fever virus through reverse vaccinology and immunoinformatics approaches.Scientific reports · 2022Article
- Temperature-Inducible Precision-Guided Sterile Insect Technique.The CRISPR journal · 2021Article
- A novel injury paradigm in the central nervous system of adult Drosophila: molecular, cellular and functional aspects.Disease models & mechanisms · 2021Article
- AG3 (Bethesda, Md.) · 2018Article
- Bivalency inFlyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An ideal transgenic gene expression system is inducible, non-leaky, and well tolerated by the target organism. While the former has been satisfactorily realized, leakiness and heavy physiological burden imposed by the existing systems are still prominent hurdles in their successful implementation. Here we describe a new system for non-leaky expression of transgenes in Drosophila. PRExpress is based on a single transgenic construct built from endogenous components, the inducible hsp70 promoter and a multimerized copy of a Polycomb response element (PRE) controlled by epigenetic chromatin regulators of the Polycomb group. We show that this system is non-leaky, rapidly and strongly inducible, and reversible. To make the application of PRExpress user-friendly, we deliver the construct via site-specific integration.
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