ArticleMolecular psychiatry2018
Selective activation of parvalbumin interneurons prevents stress-induced synapse loss and perceptual defects.
Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 109 citations in OpenAlex.
- Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026Review
- Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity.Nature communications · 2026Article
- TARGETING INSULO-FRONTAL PATHWAY TO REDUCE STRESS-EVOKED COGNITIVE RIGIDITY.bioRxiv : the preprint server for biology · 2026Article
- Coordinated cellular architecture reveals weakened cortical structure-behavior coupling in normal aging.Frontiers in aging neuroscience · 2026Article
- Adolescent stress exposure induces persistent, sex-specific cognitive deficits.Neurobiology of learning and memory · 2025Article
- Disruption in Patterning in the Whisker-to-Barrel Cortex Pathway Alters Behavior.bioRxiv : the preprint server for biology · 2025Article
- Single-cell transcriptomics reveals Sox6 positive interneurons enriched in the prefrontal cortex of female mice vulnerable to chronic social stress.Molecular psychiatry · 2025Article
- Prefrontal parvalbumin interneurons mediate CRHR1-dependent early-life stress-induced cognitive deficits in adolescent male mice.Molecular psychiatry · 2025Article
- Targeting microglial NAAA-regulated PEA signaling counters inflammatory damage and symptom progression of post-stroke anxiety.Cell communication and signaling : CCS · 2025Article
- Fam172a Mediates the Stimulation of Hypothalamic Oxytocin Neurons to Suppress Obesity-Induced Anxiety.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Structural neural plasticity evoked by rapid-acting antidepressant interventions.Nature reviews. Neuroscience · 2025Review
- Repeated stress gradually impairs auditory processing and perception.PLoS biology · 2025Article
- Complement and microglia activation mediate stress-induced synapse loss in layer 2/3 of the medial prefrontal cortex in male mice.Nature communications · 2024Article
- Transcriptome dynamics in mouse amygdala under acute and chronic stress revealed by thiol-labeled RNA sequencing.Neurobiology of stress · 2024Article
- Repeated exposure to multiple concurrent stressors alters visual processing in the adult posterior parietal cortex.Neurobiology of stress · 2024Article
- Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation.iScience · 2024Article
- SynCAM1 deficiency in the hippocampal parvalbumin interneurons contributes to sevoflurane-induced cognitive impairment in neonatal rats.CNS neuroscience & therapeutics · 2024Article
- The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology.Nature communications · 2023Article
- Velocity of conduction between columns and layers in barrel cortex reported by parvalbumin interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Multi-synaptic boutons are a feature of CA1 hippocampal connections in the stratum oriens.Cell reports · 2023Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Stress, a prevalent experience in modern society, is a major risk factor for many psychiatric disorders. Although sensorimotor abnormalities are often present in these disorders, little is known about how stress affects the sensory cortex. Combining behavioral analyses with in vivo synaptic imaging, we show that stressful experiences lead to progressive, clustered loss of dendritic spines along the apical dendrites of layer (L) 5 pyramidal neurons (PNs) in the mouse barrel cortex, and such spine loss closely associates with deteriorated performance in a whisker-dependent texture discrimination task. Furthermore, the activity of parvalbumin-expressing inhibitory interneurons (PV+ INs) decreases in the stressed mouse due to reduced excitability of these neurons. Importantly, both behavioral defects and structural changes of L5 PNs are prevented by selective pharmacogenetic activation of PV+INs in the barrel cortex during stress. Finally, stressed mice raised under environmental enrichment (EE) maintain normal activation of PV+ INs, normal texture discrimination, and L5 PN spine dynamics similar to unstressed EE mice. Our findings suggest that the PV+ inhibitory circuit is crucial for normal synaptic dynamics in the mouse barrel cortex and sensory function. Pharmacological, pharmacogenetic and environmental approaches to prevent stress-induced maladaptive behaviors and synaptic malfunctions converge on the regulation of PV+ IN activity, pointing to a potential therapeutic target for stress-related disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.