Evidence map›Paper›PMID 28761049›Full record

ArticleScientific reports2017

Improving cartilage phenotype from differentiated pericytes in tunable peptide hydrogels.

Enateri V Alakpa, Vineetha Jayawarna, Karl E V Burgess, Christopher C West, Bruno Péault, Rein V Ulijn, Matthew J Dalby

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Blood Vessel Resident Human Stem Cells in Health and Disease.Stem cells translational medicine · 2022
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Five Decades Later, Are Mesenchymal Stem Cells Still Relevant?Frontiers in bioengineering and biotechnology · 2020
    Review
  10. Perivascular Mesenchymal Progenitors for Bone Regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019
    Review
  11. Article
  12. New substrates for stem cell control.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  13. Multicomponent peptide assemblies.Chemical Society reviews · 2018
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Enateri V AlakpaInstitution for Integrative Medical Biology, Umeå University, SE901 87, Umeå, Sweden. Enateri.Alakpa@umu.se.
Vineetha JayawarnaCentre for Cell Engineering, Institute of Molecular, Cell & Systems Biology, College of Medical, Veterinary & Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK.
Karl E V BurgessScottish Polyomics Facility, Wolfson Wohl Cancer Research Centre, College of Medical, Veterinary & Life Sciences, University of Glasgow, Garscube Estate, Glasgow, G61 1QH, UK.
Christopher C WestCentre for Regenerative Medicine and Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, EH16 4UU, UK.
Bruno PéaultCentre for Regenerative Medicine and Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, EH16 4UU, UK.
Rein V UlijnAdvanced Science Research Center (ASRC), University of New York, New York, NY, 10031, USA.
Matthew J DalbyCentre for Cell Engineering, Institute of Molecular, Cell & Systems Biology, College of Medical, Veterinary & Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK.
University of Glasgow · GBBroad Center · USCUNY Advanced Science Research Center · USMRC Centre for Regenerative Medicine · GBUmeå University · SE

Funding

Biotechnology and Biological Sciences Research Council BB/J018902/1Biotechnology and Biological Sciences Research Council BB/K006908/1Chief Scientist Office CAF/11/13Medical Research Council G1000816
6 · The paper itself

Abstract

Differentiation of stem cells to chondrocytes in vitro usually results in a heterogeneous phenotype. This is evident in the often detected over expression of type X collagen which, in hyaline cartilage structure is not characteristic of the mid-zone but of the deep-zone ossifying tissue. Methods to better match cartilage developed in vitro to characteristic in vivo features are therefore highly desirable in regenerative medicine. This study compares phenotype characteristics between pericytes, obtained from human adipose tissue, differentiated using diphenylalanine/serine (F

Indexed as

Adipose TissueBiomarkersCell DifferentiationCells, CulturedChondrocytesChondrogenesisCollagen Type IIDipeptidesHumansHydrogelsMetabolomicsPeptidesPericytesPhenotypePhenylalanineTissue EngineeringBiomarkersCollagen Type IIDipeptidesHydrogelsPeptidesPhenylalaninephenylalanylphenylalanine

Identifiers

PMID28761049
PMCPMC5537289
OpenAlexW2736751563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.