ArticleProceedings of the National Academy of Sciences of the United States of America2017
Low-frequency hippocampal-cortical activity drives brain-wide resting-state functional MRI connectivity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.International journal of molecular sciences · 2022Pooled it
- Functional Magnetic Resonance Imaging for Investigating the Role of the Hippocampus in Migraine with Aura.Diagnostics (Basel, Switzerland) · 2026Article
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
- Switching Patterns of Cortical-Subcortical Interaction in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- [Analyzing Frequency-Dependent Human Brain Information Flow in Resting-State fMRI Using Multiple Effective Connectivity Methods].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Randomized prenatal and postnatal nutrient supplementation shows no long-term impact on cortical gray matter in Ghanaian children.Frontiers in human neuroscience · 2025Article
- Gray matter volume microstructural alterations in chronic post-burn pruritus: a voxel-based morphometry analysis using 3D T1-weighted imaging.Frontiers in neuroscience · 2025Article
- Subsegmentation of the hippocampus in subgroups of migraine with aura patients: advanced structural neuroimaging study.The journal of headache and pain · 2024Article
- NOise Reduction with DIstribution Corrected (NORDIC) principal component analysis improves brain activity detection across rodent and human functional MRI contexts.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Modeling the neurocognitive dynamics of language across the lifespan.Human brain mapping · 2024Article
- Neuronal basis of high frequency fMRI fluctuation: direct evidence from simultaneous recording.Frontiers in human neuroscience · 2024Article
- Functional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation.Nature communications · 2023Article
- Altered whole-brain gray matter volume in form-deprivation myopia rats based on voxel-based morphometry: A pilot study.Frontiers in neuroscience · 2023Article
- Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression.Science advances · 2022Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
The hippocampus, including the dorsal dentate gyrus (dDG), and cortex engage in bidirectional communication. We propose that low-frequency activity in hippocampal-cortical pathways contributes to brain-wide resting-state connectivity to integrate sensory information. Using optogenetic stimulation and brain-wide fMRI and resting-state fMRI (rsfMRI), we determined the large-scale effects of spatiotemporal-specific downstream propagation of hippocampal activity. Low-frequency (1 Hz), but not high-frequency (40 Hz), stimulation of dDG excitatory neurons evoked robust cortical and subcortical brain-wide fMRI responses. More importantly, it enhanced interhemispheric rsfMRI connectivity in various cortices and hippocampus. Subsequent local field potential recordings revealed an increase in slow oscillations in dorsal hippocampus and visual cortex, interhemispheric visual cortical connectivity, and hippocampal-cortical connectivity. Meanwhile, pharmacological inactivation of dDG neurons decreased interhemispheric rsfMRI connectivity. Functionally, visually evoked fMRI responses in visual regions also increased during and after low-frequency dDG stimulation. Together, our results indicate that low-frequency activity robustly propagates in the dorsal hippocampal-cortical pathway, drives interhemispheric cortical rsfMRI connectivity, and mediates visual processing.
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