Evidence map›Paper›PMID 28760971›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Cytokine signature associated with disease severity in chronic fatigue syndrome patients.

Jose G Montoya, Tyson H Holmes, Jill N Anderson, Holden T Maecker, Yael Rosenberg-Hasson, Ian J Valencia, Lily Chu, Jarred W Younger, Cristina M Tato, Mark M Davis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 241 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
241citing papers in PubMed, 8 pooled it
26.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

241 citing papers in PubMed, 8 syntheses or guidelines pooled it, 417 citations in OpenAlex.

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181 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jose G MontoyaDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Tyson H HolmesDivision of Infectious Diseases and Geographic Medicine; Stanford University School of Medicine, Stanford, CA 94305.
Jill N AndersonDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Holden T MaeckerInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305.
Yael Rosenberg-HassonInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305.
Ian J ValenciaDivision of Infectious Diseases and Geographic Medicine; Stanford University School of Medicine, Stanford, CA 94305.
Lily ChuDivision of Infectious Diseases and Geographic Medicine; Stanford University School of Medicine, Stanford, CA 94305.
Jarred W YoungerDepartment of Anesthesiology, Stanford University School of Medicine, Stanford, CA 94305.
Cristina M TatoInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305.
Mark M DavisInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305; mmdavis@stanford.edu.
Stanford University · USHoward Hughes Medical Institute · US

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Howard Hughes Medical InstituteNIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

Although some signs of inflammation have been reported previously in patients with myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), the data are limited and contradictory. High-throughput methods now allow us to interrogate the human immune system for multiple markers of inflammation at a scale that was not previously possible. To determine whether a signature of serum cytokines could be associated with ME/CFS and correlated with disease severity and fatigue duration, cytokines of 192 ME/CFS patients and 392 healthy controls were measured using a 51-multiplex array on a Luminex system. Each cytokine's preprocessed data were regressed on ME/CFS severity plus covariates for age, sex, race, and an assay property of newly discovered importance: nonspecific binding. On average, TGF-β was elevated (

Indexed as

AdultAgedBiomarkersCase-Control StudiesChemokine CXCL1Chemokine CXCL10CytokinesFatigue Syndrome, ChronicFemaleHumansMaleMiddle AgedSeverity of Illness IndexTransforming Growth Factor beta1BiomarkersChemokine CXCL1Chemokine CXCL10CytokinesTransforming Growth Factor beta1chronic fatigue syndromecytokinesimmune monitoringmyalgic encephalomyelitisseverity

Identifiers

PMID28760971
PMCPMC5576836
OpenAlexW2741112791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.