Evidence map›Paper›PMID 28760964›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Metal-mediated diradical tuning for DNA replication arrest via template strand scission.

Meghan R Porter, Sarah E Lindahl, Anne Lietzke, Erin M Metzger, Quan Wang, Erik Henck, Chun-Hsing Chen, Hengyao Niu, Jeffrey M Zaleski

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Characterization and initial demonstration ofInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2022
    Article
  2. Article
  3. Article
  4. Article
  5. Designed metalloenediyne warheads damage DNA and outpace DNA polymerase.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Meghan R PorterDepartment of Chemistry, Indiana University, Bloomington, IN 47405.
Sarah E LindahlDepartment of Chemistry, Indiana University, Bloomington, IN 47405.
Anne LietzkeDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405.
Erin M MetzgerDepartment of Chemistry, Indiana University, Bloomington, IN 47405.
Quan WangDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405.
Erik HenckDepartment of Chemistry, Indiana University, Bloomington, IN 47405.
Chun-Hsing ChenMolecular Structure Center, Indiana University, Bloomington, IN 47405.
Hengyao NiuDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405; zaleski@indiana.edu hniu@indiana.edu.
Jeffrey M ZaleskiDepartment of Chemistry, Indiana University, Bloomington, IN 47405; zaleski@indiana.edu hniu@indiana.edu.
Indiana University Bloomington · US

Funding

The Development of Thermally-activated Metalloenediynes for Cancer TherapyR01CA196293 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI DYNLACHT, JOSEPH R, ZALESKI, JEFFREY M · 2015 to 2019
$2.4M
Mechanisms and Crosstalk of DNA Break Resection PathwaysR00ES021441 · NIEHS · TRUSTEES OF INDIANA UNIVERSITY · PI NIU, HENGYAO · 2015 to 2017
$747k
NCI NIH HHS R01 CA196293NIEHS NIH HHS R00 ES021441
6 · The paper itself

Abstract

A series of M(PyED)·X (X = 2Cl

Indexed as

Chelating AgentsCrystallography, X-RayCyclizationDNA DamageDNA ReplicationDrug DesignElectron Spin Resonance SpectroscopyFree RadicalsHeLa CellsHumansLigandsMolecular StructureOrganometallic CompoundsPyridinesChelating AgentsFree RadicalsLigandsOrganometallic CompoundsPyridinesBergman cyclizationDNA degradationenediynemetal-mediated radicalspolymerase inhibition

Identifiers

PMID28760964
PMCPMC5594643
OpenAlexW2740321793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.