Evidence map›Paper›PMID 28760934›Full record

ArticleInfection and immunity2017

Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis.

Jennifer K Spinler, Jennifer Auchtung, Aaron Brown, Prapaporn Boonma, Numan Oezguen, Caná L Ross, Ruth Ann Luna, Jessica Runge, James Versalovic, Alex Peniche and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. mSphere · 2025
    Article
  9. Review
  10. Non-invasive treatment ofFrontiers in microbiology · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Decolonizing drug-resistantMicrobiology (Reading, England) · 2023
    Article
  16. Review
  17. Probiotics: insights and new opportunities forCritical reviews in microbiology · 2023
    Review
  18. Article
  19. Unveiling the inhibition mechanism ofFrontiers in microbiology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Jennifer K SpinlerDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA spinler@bcm.edu.ORCID http://orcid.org/0000-0002-7830-7665
Jennifer AuchtungAlkek Center for Metagenomics & Microbiome Research, Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Aaron BrownDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
Prapaporn BoonmaDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
Numan OezguenDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
Caná L RossDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
Ruth Ann LunaDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
Jessica RungeDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
James VersalovicDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
Alex PenicheDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Sara M DannDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Robert A BrittonAlkek Center for Metagenomics & Microbiome Research, Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Anthony HaagDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
Tor C SavidgeDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
Baylor College of Medicine · USThe University of Texas Medical Branch at Galveston · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
UTMB Clinical and Translational Science AwardUL1TR000071 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRASIER, ALLAN R. · 2012 to 2014
$14.4M
Decoding Antibiotic-induced Susceptibility to Clostridium difficile InfectionU01AI124290 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BRITTON, ROBERT A, GAREY, KEVIN W · 2016 to 2020
$7.9M
The Impact of Microbiome Composition, Diversity, and Function on Enteric DiseaseU19AI090872 · NIAID · MICHIGAN STATE UNIVERSITY · PI MANSFIELD, LINDA S. · 2010 to 2014
$7.1M
Metabolome-Based Biomarkers and Neutraceuticals in Clostridium Difficile InfectionR21DK096323 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SAVIDGE, TOR C. · 2014 to 2015
$433k
NCATS NIH HHS UL1 TR000071NIAID NIH HHS U01 AI124290NIAID NIH HHS U19 AI090872NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R21 DK096323
6 · The paper itself

Abstract

Integration of antibiotic and probiotic therapy has the potential to lessen the public health burden of antimicrobial-associated diseases.

Indexed as

ProbioticsAnti-Bacterial AgentsBacterial ProteinsClostridioides difficileClostridium InfectionsDrug DiscoveryDrug Resistance, BacterialFecesFermentationGastrointestinal MicrobiomeGlyceraldehydeGlycerolHumansLimosilactobacillus reuteriMetabolomicsPropane3-hydroxypropionaldehydeAnti-Bacterial AgentsBacterial ProteinsGlyceraldehydeGlycerolPropaneVancomycinantimicrobial resistanceClostridium difficileLactobacillus reuterinext-generation probioticsreuterin

Identifiers

PMID28760934
PMCPMC5607411
OpenAlexW2741189003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.