Evidence map›Paper›PMID 28760932›Full record

ArticleInfection and immunity2017

Tpl2 Promotes Innate Cell Recruitment and Effector T Cell Differentiation To Limit Citrobacter rodentium Burden and Dissemination.

Nicole V Acuff, Xin Li, Krishna Latha, Tamas Nagy, Wendy T Watford

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicole V AcuffDepartment of Infectious Diseases, University of Georgia, Athens, Georgia, USA.
Xin LiDepartment of Infectious Diseases, University of Georgia, Athens, Georgia, USA.
Krishna LathaDepartment of Infectious Diseases, University of Georgia, Athens, Georgia, USA.
Tamas NagyDepartment of Pathology, University of Georgia, Athens, Georgia, USA.
Wendy T WatfordDepartment of Infectious Diseases, University of Georgia, Athens, Georgia, USA watfordw@uga.edu.
University of Georgia · US

Funding

MAP3K8-mediated regulation of adaptive immune responses and autoimmunityR01AI099058 · NIAID · UNIVERSITY OF GEORGIA · PI WATFORD, WENDY T · 2013 to 2017
$1.6M
NIAID NIH HHS R01 AI099058
6 · The paper itself

Abstract

Tumor progression locus 2 (Tpl2) is a serine-threonine kinase that regulates Th1 differentiation, secretion of the inflammatory cytokine gamma interferon (IFN-γ), and host defense against the intracellular pathogens

Indexed as

AnimalsBacterial LoadCD4-Positive T-LymphocytesCell DifferentiationCitrobacter rodentiumEnterobacteriaceae InfectionsGastrointestinal DiseasesInterferon-gammaInterleukin-17IntestinesMAP Kinase Kinase KinasesMiceMice, Inbred C57BLMice, KnockoutNeutrophilsProto-Oncogene ProteinsInterferon-gammaInterleukin-17Map3k8 protein, mouseMAP Kinase Kinase KinasesProto-Oncogene ProteinsCitrobactergastrointestinal infectionintestinal immunityneutrophilsT helper cells

Identifiers

PMID28760932
PMCPMC5607429
OpenAlexW2742076806

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.