Evidence map›Paper›PMID 28760906›Full record

ArticleAntimicrobial agents and chemotherapy2017

Mechanisms of Action of Vitamin D as Supplemental Therapy for Pneumocystis Pneumonia.

Guang-Sheng Lei, Chen Zhang, Bi-Hua Cheng, Chao-Hung Lee

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 6 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Relationship between Vitamin D and Immunity in Older People with COVID-19.International journal of environmental research and public health · 2023
    Review
  13. Vitamin D-A prominent immunomodulator to prevent COVID-19 infection.International journal of rheumatic diseases · 2023
    Review
  14. Review
  15. Article
  16. Vitamin D Regulation of Immune Function.Current osteoporosis reports · 2022
    Review
  17. Article
  18. Review
  19. Vitamin D regulation of immune function during covid-19.Reviews in endocrine & metabolic disorders · 2022
    Review
  20. The Role of Vitamin D in Supporting Health in the COVID-19 Era.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Guang-Sheng LeiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Chen ZhangDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Bi-Hua ChengDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Chao-Hung LeeDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA chlee@iupui.edu.
Indiana University School of MedicineChiayi Chang Gung Memorial Hospital · TWIndiana University – Purdue University Indianapolis · US

Funding

Vitamin D as Supplemental Therapy for Pneumocystis PneumoniaR21AI122837 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI LEE, CHAO-HUNG · 2016 to 2017
$430k
NIAID NIH HHS R21 AI122837
6 · The paper itself

Abstract

The combination of trimethoprim and sulfamethoxazole (TMP-SMX) is the most effective regimen for therapy of

Indexed as

AnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAutophagy-Related Protein 5Beclin-1CathelicidinsDrug SynergismFemaleGlutamate-Cysteine LigaseGlutathione ReductaseHumansInterferon-gammaInterleukin-6Macrophages, AlveolarMiceMice, Inbred C57BLAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAtg5 protein, mouseAutophagy-Related Protein 5Beclin-1CathelicidinsGCLM protein, mouseGlutamate-Cysteine LigaseGlutathione ReductaseInterferon-gammaInterleukin-6interleukin-6, mouseNitric Oxide Synthase Type IINos2 protein, mousePrimaquineTrimethoprim, Sulfamethoxazole Drug CombinationTumor Necrosis Factor-alphaVitamin Dalveolar macrophagesPneumocystis pneumoniavitamin D3

Identifiers

PMID28760906
PMCPMC5610499
OpenAlexW2741366635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.