Evidence map›Paper›PMID 28760902›Full record

ArticleAntimicrobial agents and chemotherapy2017

Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins.

Pankaj Kumar, Varsha Chauhan, José Rogério A Silva, Jerônimo Lameira, Felipe B d'Andrea, Shao-Gang Li, Stephan L Ginell, Joel S Freundlich, Cláudio Nahum Alves, Scott Bailey and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 77 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  5. Article
  6. Peptidoglycan LD-Transpeptidases.Antibiotics (Basel, Switzerland) · 2025
    Review
  7. Oral β-lactam combinations are effectiveMicrobiology spectrum · 2025
    Article
  8. Article
  9. Article
  10. Novel C5α-substituted carbapenems enhanceAntimicrobial agents and chemotherapy · 2025
    Article
  11. Article
  12. Article
  13. Toward better cures forClinical microbiology reviews · 2024
    Review
  14. Review
  15. Evolution toward extremely high imipenem resistance inAntimicrobial agents and chemotherapy · 2024
    Article
  16. Dual β-lactam for treatment of pulmonaryAntimicrobial agents and chemotherapy · 2024
    Article
  17. Case Commentary: Dual β-lactam as part of regimen to treatAntimicrobial agents and chemotherapy · 2024
    Article
  18. Article
  19. Evolution towards extremely high β-lactam resistance inbioRxiv : the preprint server for biology · 2024
    Article
  20. Management ofJournal of clinical tuberculosis and other mycobacterial diseases · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Pankaj KumarCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Varsha ChauhanCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
José Rogério A SilvaPrograma de Pós-Graduação em Química Medicinal e Modelagem Molecular, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.
Jerônimo LameiraPrograma de Pós-Graduação em Química Medicinal e Modelagem Molecular, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.
Felipe B d'AndreaTaskforce To Study Resistance Emergence and Antimicrobial Development Technology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Shao-Gang LiDepartments of Pharmacology, Physiology and Neuroscience, and Medicine, Rutgers University, Newark, New Jersey, USA.
Stephan L GinellBiosciences Division, Argonne National Laboratory, Argonne, Illinois, USA.
Joel S FreundlichDepartments of Pharmacology, Physiology and Neuroscience, and Medicine, Rutgers University, Newark, New Jersey, USA.
Cláudio Nahum AlvesPrograma de Pós-Graduação em Química Medicinal e Modelagem Molecular, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.
Scott BaileyDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keira A CohenDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Gyanu LamichhaneCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA lamichhane@jhu.edu.ORCID 0000-0002-2214-0114
Johns Hopkins University · USUniversidade Federal do Pará · BRRutgers, The State University of New Jersey · USArgonne National Laboratory · USBrigham and Women's Hospital · US

Funding

New Drug for Treatment of Chronic Bacterial InfectionDP2OD008459 · OD · JOHNS HOPKINS UNIVERSITY · PI LAMICHHANE, GYANU · 2011 to 2013
$2.6M
Towards a new regimen to treat mycobacterial infection in cystic fibrosis patientsR21AI121805 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LAMICHHANE, GYANU · 2016 to 2017
$446k
NIAID NIH HHS R21 AI121805NIH HHS DP2 OD008459
6 · The paper itself

Abstract

As a growing number of clinical isolates of

Indexed as

Anti-Bacterial AgentsCarbapenemsCell WallCephalosporinsCrystallography, X-RayDrug SynergismMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationMycobacterium abscessusMycobacterium Infections, NontuberculousPenicillinsPeptidoglycanPeptidyl TransferasesProtein Structure, TertiaryAnti-Bacterial AgentsCarbapenemsCephalosporinsPenicillinsPeptidoglycanPeptidyl Transferasesbeta-lactamscarbapenemcephalosporinl,d-transpeptidaseMycobacterium abscessus

Identifiers

PMID28760902
PMCPMC5610527
OpenAlexW2742076607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.