Evidence map›Paper›PMID 28760881›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms.

Anna Iacoangeli, Anita Lui, Ashley Haines, Yuko Ohta, Martin Flajnik, Ellen Hsu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. A cold-blooded view of adaptive immunity.Nature reviews. Immunology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Anna IacoangeliTisch Multiple Sclerosis Research Center of New York, New York, NY 10019.ORCID 0000-0001-8881-9536
Anita LuiDepartment of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203; and.
Ashley HainesDepartment of Microbiology and Immunology, University of Maryland Baltimore, Baltimore, MD 21201.ORCID 0000-0001-7662-2058
Yuko OhtaDepartment of Microbiology and Immunology, University of Maryland Baltimore, Baltimore, MD 21201.
Martin FlajnikDepartment of Microbiology and Immunology, University of Maryland Baltimore, Baltimore, MD 21201.
Ellen HsuDepartment of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203; and hsue@hscbklyn.edu.
University of Maryland, Baltimore · USState University of New York · USTisch Hospital · US

Funding

Isotype Exclusion and Hypermutation in the Nurse SharkR01GM068095 · NIGMS · SUNY DOWNSTATE MEDICAL CENTER · PI HSU, ELLEN · 2004 to 2017
$3.1M
Evolution of Adaptive ImmunityR01OD010549 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI FLAJNIK, MARTIN F · 2013 to 2017
$1.7M
NIGMS NIH HHS R01 GM068095NIH HHS R01 OD010549
6 · The paper itself

Abstract

Unlike most vertebrates, the shark IgL gene organization precludes secondary rearrangements that delete self-reactive VJ rearranged genes. Nurse sharks express four L chain isotypes, κ, λ, σ, and σ-2, encoded by 35 functional minigenes or clusters. The sequence of gene activation/expression and receptor editing of these isotypes have not been studied. We therefore investigated the extent of isotypic exclusion in separated B cell subpopulations. Surface Ig (sIg)κ-expressing cells, isolated with mAb LK14 that recognizes Cκ, carry predominantly nonproductive rearrangements of other L chain isotypes. Conversely, after depletion with LK14, sIgM

Indexed as

Gene Rearrangement, B-Lymphocyte, Light ChainAnimalsB-LymphocytesB-Lymphocyte SubsetsCells, CulturedFemaleFish ProteinsGene Expression RegulationGenetic LociGenetic StructuresImmunoglobulin Class SwitchingImmunoglobulin IsotypesImmunoglobulin Light ChainsMaleReceptors, Antigen, B-CellRNA, MessengerFish ProteinsImmunoglobulin IsotypesImmunoglobulin Light ChainsReceptors, Antigen, B-CellRNA, Messenger

Identifiers

PMID28760881
PMCPMC5563170
OpenAlexW2741505066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.