Evidence map›Paper›PMID 28760868›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Polysialylation at Early Stages of Oligodendrocyte Differentiation Promotes Myelin Repair.

Sebastian Werneburg, Hazel L S Fuchs, Iris Albers, Hannelore Burkhardt, Viktoria Gudi, Thomas Skripuletz, Martin Stangel, Rita Gerardy-Schahn, Herbert Hildebrandt

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

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  6. Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sebastian WerneburgInstitute of Clinical Biochemistry, and.
Hazel L S FuchsInstitute of Clinical Biochemistry, and.
Iris AlbersInstitute of Clinical Biochemistry, and.
Hannelore BurkhardtInstitute of Clinical Biochemistry, and.
Viktoria GudiClinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, and.
Thomas SkripuletzClinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, and.
Martin StangelClinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, 30625 Hannover, Germany, and.
Rita Gerardy-SchahnInstitute of Clinical Biochemistry, and.
Herbert HildebrandtInstitute of Clinical Biochemistry, and hildebrandt.herbert@mh-hannover.de.ORCID 0000-0002-1044-0881
Institute of Clinical Research · USMedizinische Hochschule Hannover · DELeibniz University Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polysialic acid is a glycan modification of the neural cell adhesion molecule (NCAM) produced by the polysialyltransferases ST8SIA2 and ST8SIA4. Polysialic acid has been detected in multiple sclerosis plaques, but its beneficial or adverse role in remyelination is elusive. Here, we show that, despite a developmental delay, myelination at the onset and during cuprizone-induced demyelination was unaffected in male

Indexed as

AnimalsCD56 AntigenCell DifferentiationCells, CulturedDemyelinating DiseasesEmbryonic Stem CellsHumansMaleMiceMice, Inbred C57BLMice, KnockoutMotor ActivityMyelin SheathNeural Cell Adhesion Molecule L1OligodendrogliaRandom AllocationCD56 AntigenCMP-N-acetylneuraminate-poly-alpha-2,8-sialosyl sialyltransferaseNcam1 protein, mouseNeural Cell Adhesion Molecule L1polysialic acidpolysialyl neural cell adhesion moleculeSialic AcidsSialyltransferasesST8SiaIV protein, mousedemyelinating diseasesdevelopmental myelinationoligodendrocyte precursorspolysialic acidpolysialyltransferasesPSA-NCAM

Identifiers

PMID28760868
PMCPMC6596786
OpenAlexW2739663379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.