Evidence map›Paper›PMID 28760863›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus.

Luke T Stewart, Anas U Khan, Kai Wang, Diana Pizarro, Sandipan Pati, Susan C Buckingham, Michelle L Olsen, John C Chatham, Lori L McMahon

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Luke T StewartDepartment of Cell, Developmental, and Integrative Biology.ORCID 0000-0003-4069-0862
Anas U KhanDepartment of Cell, Developmental, and Integrative Biology.ORCID 0000-0003-3299-2983
Kai WangDepartment of Cell, Developmental, and Integrative Biology.
Diana PizarroDepartment of Neurology.ORCID 0000-0002-2429-4563
Sandipan PatiDepartment of Neurology.
Susan C BuckinghamDepartment of Neurobiology, and.ORCID 0000-0003-2483-3544
Michelle L OlsenDepartment of Cell, Developmental, and Integrative Biology.
John C ChathamDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Lori L McMahonDepartment of Cell, Developmental, and Integrative Biology, mcmahon@uab.edu.
Neurology, Inc · USInstitute of Neurobiology · BGIntegrative Medicine Institute · USUniversity of Alabama at Birmingham · US

Funding

Epigenetic Regulation of Kir4.1 and GLT1 in PathophysiologyR01NS075062 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OLSEN, MICHELLE L · 2013 to 2017
$1.6M
O-GlcNAcylation and Hippocampal Synaptic PlasticityR01NS076312 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHATHAM, JOHN C, MCMAHON, LORI LYNN · 2011 to 2015
$1.6M
O-GlcNAcylation dampens hyper-excitability in hippocampus during acute epileptiform activityF31NS095568 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEWART, LUKE THOMAS · 2015 to 2016
$68k
NINDS NIH HHS F31 NS095568NINDS NIH HHS R01 NS075062NINDS NIH HHS R01 NS076312
6 · The paper itself

Abstract

O-GlcNAcylation is a ubiquitous and dynamic post-translational modification involving the O-linkage of β-

Indexed as

AcetylglucosamineAnimalsEpilepsyFemaleGlycosylationHippocampusLong-Term Synaptic DepressionMaleMiceMice, Inbred C57BLMice, TransgenicOrgan Culture TechniquesProtein Processing, Post-TranslationalRatsRats, Sprague-DawleyAcetylglucosamineglutamate transmissionneuronal excitationO-GlcNAcpost-translational modificationsynaptic circuits

Identifiers

PMID28760863
PMCPMC5566868
OpenAlexW2740113329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.